Dynamics of Deformable Drops and Biomimetic Capsules in Microfluidic Systems

[66904] [au:]近年来，人们越来越清楚地认识到，提高对高受限可变形颗粒流体动力学的理解，对于开发微流体技术的全部潜力是非常重要的。特别有前途的是微流体装置的发展，以测定细胞膜的力学参数，用于筛选某些疾病。原则上，这种装置可以使用当前的微流体制造技术来构建，但它们还没有开发出来，至少部分原因是缺乏关于典型微流体中可变形颗粒的微流体动力学的基本知识。不合理的体系结构和缺乏合适的数值公式。这个项目的目标是推进对微观环境中可变形粒子集体动力学的基本理解。Uidic网络并探索使用micro的可行性&amp；根据颗粒的可变形性来区分颗粒的设备。这项研究包括紧密耦合的实验和数值模拟。具体目标包括：(1)开发具有定制变形特性的囊泡、胶囊和滴剂的可控合成方法；利用这些颗粒进行实验，探讨颗粒动力学对变形参数的依赖关系；(2)设计制造新型微处理器&amp；#64258；探索基于可变形性参数分选囊泡和液滴的可行性；(3)发展微环境下高受限变形粒子的多粒子计算机模拟；通道和通道之间的连接处。长期以来，了解微通道中可变形颗粒的动力学一直被认为是多种现象的重要方面，如石油开采和炼油作业、环境修复和微循环中的血液流动。对这一问题的基本理解是开发用于生物分析应用的微流体装置的核心，这些应用通常涉及微观可变形颗粒的流动。提出的研究将进一步对受限变形粒子的集体动力学有一个基本的了解。因此，该项目将为广泛应用的微流体装置的设计和优化提供一个合理的框架。此外，该项目可能会导致新的生物医学设备，用于根据细胞的机械性能分选细胞，以及根据可变形性分析细胞群体的患病状态。参与本研究的研究生将获得广泛的工程科学和数学背景。拟议的研究将通过与项目相关的REU项目为本科生提供研究机会。

1066904PI: OsujiIn recent years it has become clear that improved understanding of the hydrodynamics of highly-confined deformable particles is important for exploiting the full potential of microfluidic technology. Particularly promising is the development of microfluidic devices to assay the mechanical parameters of cell membranes for use in screening for certain diseases. In principle, such devices could be constructed using the current microfluidic fabrication techniques, yet they have not been developed, at least in part because of a lack of fundamental knowledge about the micro-hydrodynamics of deformable particles in typical microfluidic architectures and the absence of a suitable numerical formulation.The goal of this project is to advance a fundamental understanding of the collective dynamics of deformable particles in microfluidic networks and to explore the feasibility of using microfluidic devices to differentiate particles based on their deformability. The investigation involves closely coupled experiments and numerical simulations. The specific objectives include: (1) to develop robust methods for controlled synthesis of vesicles, capsules, and drops with tailored deformation properties; to conduct experiments using these particles to explore the dependence of particle dynamics on deformation parameters; (2) to design and fabricate novel microfluidic devices to explore the feasibility of sorting vesicles and drops based on deformability parameters; and (3) to develop many-particle computer simulation of highly-confined deformable particles in microfluidic channels and at junctions between channels. Understanding the dynamics of deformable particles in microchannels has long been recognized an important aspect of diverse phenomena such as oil recovery and refining operations, environmental remediation, and blood flow in the microcirculation. A fundamental understanding of this problem is central to the development of microfluidic devices for bio-analytical applications that often involve flows of microscopic deformable particles. The proposed investigation will further a basic understanding of the collective dynamics of confined deformable particles. This project will thus advance a rational framework for the design and optimization of microfluidic devices for a broad class of applications. Moreover, this project may lead to new biomedical devices for sorting cells based on their mechanical properties as well as assaying cell populations for diseased states based on deformability.Graduate students involved in this study will acquire a broad engineering science and mathematics background. The proposed study will provide undergraduates with exposure to research through REU projects related to the project.