GOALI: Implementation of Biodegradable Material Models in ANSYS

1067750MooreDesign许多生物可降解医疗植入物的优化受到缺乏适当建模工具的阻碍。在这些应用中，植入物？的几何形状和它所承受的机械载荷可能相当复杂。这导致植入物内的空间变化的应变场，这可能导致某些部件比其他部件更快地降解。遗憾的是，对空间相关应变加速退化进行建模的能力尚未得到很好的开发，并且在医疗器械行业中常用的有限元建模（FEM）工具中完全不存在。有限元法包括使用计算技术来解决复杂几何结构中的应力问题。摩尔实验室已经开始构建应变加速生物降解过程的材料描述模型。虽然最初成功地描述了一般特征，这些模型的进一步应用需要广泛的模型细化。德克萨斯A M大学和ANSYS公司之间的GOALI提案。旨在为模型开发提供这些后续步骤。 具体而言，目标是：1。通过对几种聚合物在生理循环载荷下的生物降解行为的广泛测量，发展了初始的生物降解材料模型。通过将这些模型部署到ANSYS力学分析FEM软件包中，确保这些模型的适用性。这些建模技术的可用性将对医疗植入物设计人员非常有益，他们希望能够预测结构故障的时间。行业合作伙伴ANSYS，Inc.的参与为该项目带来了巨大的价值。他们的建模软件正被大量的医疗器械制造商所使用，他们都在努力开发可生物降解的植入物，这些模型的开发将使医疗器械设计师以外的社区受益。仍然在生物医学界，有许多努力来设计功能性组织工程结构，可以取代患病的身体部位。在许多情况下，这些结构是由可生物降解的材料制成的，这些材料被嵌入或周围细胞的作用所取代。在这个项目中开发的建模技术将适用于这些情况下，增加了代表细胞动作的参数。在生物医学领域之外，还有许多其他类型的材料经历应变加速降解的情况，包括建筑环境（人造结构），汽车和航空航天领域。这些新模型的商业可用性将使所有这些领域受益，并教育更广泛的受众了解这些新材料模型的潜在广泛利益。行业合作伙伴ANSYS，Inc.在向广大社区提供这些模式和宣传其潜在好处方面增加了重要价值。 博士后和本科生研究人员培训方面将使工程专业人数不足的群体（女性）受益。

1067750MooreDesign optimization of many biodegradable medical implants is hampered by a lack of appropriate modeling tools. In these applications, the implant?s geometry and the mechanical loads to which it is subjected may be quite complex. This leads to spatially varying strain fields within the implant, which can cause certain parts to degrade faster than others. Unfortunately, the ability to model spatially dependent strain accelerated degradation is not well developed, and completely absent in the finite element modeling (FEM) tools commonly used in the medical device industry. FEM involves using computational techniques to solve for stresses in structures with complex geometries.The Moore laboratory has begun constructing material description models for strain accelerated biodegradation processes. While initially successful in describing general characteristics, the further application of these models requires extensive model refinement. This GOALI proposal between Texas A&M University and ANSYS, Inc. aims to provide these next steps in model development. Specifically, the objectives are:1. Evolve the initial biodegradable material models through an extensive set of measurements of the biodegradation behavior of several polymers subjected to physiologic cyclic loading.2. Ensure the applicability of these models by deploying them in the ANSYS Mechanical Analysis FEM software package.The availability of such modeling techniques will be of great benefit to medical implant designers who desire a predictable time to structural breakdown. There is significant value brought to the project by the participation of the industry partner, ANSYS, Inc. Their modeling software is being used by a large number of medical device manufacturers, all of whom are trying to develop biodegradable implants.The development of these models will benefit communities other than medical device designers. Still within the biomedical community, there are many efforts to design functional tissue engineered constructs that can replace diseased body parts. In many cases, these constructs are made from biodegradable materials that are replaced by the actions of embedded or surrounding cells. The modeling techniques developed in this project will be applicable to these situations, with the addition of parameters that represent cell actions. Outside the biomedical community, there are many situations in which other sorts of materials experience strain accelerated degradation, including the built environment (man-made structures), automotive, and aerospace sectors. The commercial availability of these new models will benefit all of these fields, and educate a broader audience on the potential wide-ranging benefits of these new material models. The participation of the industry partner, ANSYS, Inc. adds significant value in making these models available to a broad community and publicizing their potential benefits. The post-doctoral and undergraduate researcher training aspects will benefit groups that are under-represented in engineering (females).