EAGER: Theoretical exploration of chiral separation via microfluidic shear flows

EAGER：通过微流体剪切流进行手性分离的理论探索

• 批准号: 1067798
• 负责人: Henry Fu
• 金额: $ 7.29万
• 依托单位: Board of Regents, NSHE, obo University of Nevada, Reno
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-10-01 至 2014-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1067798&HistoricalAwards=false
• 关键词: EAGER; Theoretical; exploration; chiral; separation

1067798FuChiral particles, or particles which are geometrically distinct from their mirror images, are prevalent in biological chemical processes. The two distinct mirror-image particles are called enantiomers. For example, naturally occurring amino acids come in only one enantiomeric type, and hence all proteins, which are constructed of amino acids, are also chiral. Since a molecule's interaction with the biochemical machinery of life is dependent of geometry, a molecule and its enantiomer can have vastly different biological effects. Therefore enantiospecific activity occurs in diverse situations including pharmaceuticals, pheromones, and odorants, and it is of clear technological importance to develop efficient ways of separating chirally pure enantiomers from mixtures which contain both enantiomers.Previous work using particles of a specific helical geometry has demonstrated that the hydrodynamic interaction of chiral particles with shear flows produces a chirality-dependent drift which can be used to separate enantiomers. However, chiral molecules typically have nonhelical geometries. In this project, we will use theoretical and computational methods to explore how geometry affects the efficiency of chiral separation in shear flows. First, we will investigate the effect of particle geometry to identify promising geometries and shear regimes both for experiments at the micrometer scale as well as the molecular scale. At the molecular scale we will focus on chiral geometries which are likely to be found in biologically active molecules. The ultimate objective is to establish the most promising avenues for further experimental studies into shear-induced chiral separation.Understanding the interaction of chiral geometries and hydrodynamic flows will impact technology as well as basic science. This research will lay out the possibilities for transforming the methods used to achieve chiral separation, which may result in more robust and cheaper methods than those in current use, which will have pharmaceutical, biological, chemical, and agricultural applications. From a scientific viewpoint, the interaction between chirality and shear is a fascinating topic of relevance to fields as diverse as sedimentation, microbial locomotion, and ecology.

1067798 FuChiral粒子，或与其镜像在几何上不同的粒子，在生物化学过程中普遍存在。这两种不同的镜像粒子称为对映体。例如，天然存在的氨基酸只有一种对映体类型，因此所有由氨基酸构成的蛋白质也是手性的。 由于分子与生命的生化机制的相互作用取决于几何形状，因此分子及其对映体可以具有截然不同的生物效应。因此，对映体特异性活性发生在不同的情况下，包括药物、信息素和气味剂，从含有两种对映异构体的混合物中分离手性纯对映异构体具有明显的技术重要性。以前使用特定螺旋几何形状的颗粒的工作已经证明，手性颗粒与剪切流的流体动力学相互作用产生手性-依赖性漂移，可用于分离对映体。 然而，手性分子通常具有非螺旋几何形状。 在这个项目中，我们将使用理论和计算方法来探索几何形状如何影响剪切流中手性分离的效率。 首先，我们将研究颗粒几何形状的影响，以确定有前途的几何形状和剪切制度的实验在微米尺度以及分子尺度。 在分子尺度上，我们将集中在手性几何形状，这是可能被发现在生物活性分子。 最终的目标是建立最有前途的途径，为进一步的实验研究到剪切诱导手性分离。了解手性几何形状和流体动力学流动的相互作用将影响技术以及基础科学。 这项研究将展示改变用于实现手性分离的方法的可能性，这可能会导致比目前使用的方法更强大，更便宜的方法，这些方法将具有制药，生物，化学和农业应用。 从科学的角度来看，手性和剪切之间的相互作用是一个迷人的主题，与沉积，微生物运动和生态学等领域有关。