Spatial Relationships Between Trabecular Bone Tissue Strain and Bone Formation

小梁骨组织应变与骨形成之间的空间关系

• 批准号: 1068260
• 负责人: Christopher Hernandez
• 金额: $ 30万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1068260&HistoricalAwards=false
• 关键词: Spatial; Relationships; Between; Trabecular; Bone

Trabecular bone is the sponge-like bone tissue present in the internal regions of bone near joints and in the vertebral centrum. It has long been known that trabecular bone structure is aligned with mechanical stresses caused by habitual activities but it remains unclear how such alignment occurs. The research goals of this project are to: 1) establish methods to determine the spatial relationship between trabecular bone tissue stress/stain and bone formation following a single bout of cyclic compressive loading; and 2) determine if the local population of osteocytes (a type of bone cell believed to be responsible for sensing mechanical stimuli) influences the spatial relationship between tissue stress/strain and bone formation. In this project osteocyte populations are determined by detecting the microscopic holes where osteocytes reside within bone tissue. Trabecular bone is a major structural component in regions of the skeleton prone to osteoporosis-related fractures (hip, wrist, spine) and understanding how mechanical stimuli influence trabecular bone structure has the potential to improve fracture risk assessment and fracture risk prevention strategies. The methods generated in the work will enhance teaching through integration into a graduate course entitled "Mechanics of Bone." Additionally, as part of this project the investigators will contribute to an annual workshop targeted to undergraduates and graduate students from an under-represented group with the goal of helping prepare the students for graduate school and careers in science and engineering. The scientific work in the project will be disseminated through presentations at scientific conferences and publications in scientific journals.

小梁骨是关节附近和椎骨内部的内部区域中存在的海绵状骨组织。 早就知道，小梁骨结构与习惯活动引起的机械应力对齐，但尚不清楚这种比对是如何发生的。 该项目的研究目标是：1）建立方法来确定小梁骨组织应力/染色与骨形成之间的空间关系； 2）确定骨细胞的局部种群（一种被认为是负责传感机械刺激的一种骨细胞）是否影响组织应力/应变和骨形成之间的空间关系。 在这个项目中，骨细胞种群是通过检测骨组织内骨细胞的微观孔来确定的。 小梁骨是容易发生骨质疏松相关裂缝（髋关节，腕，脊柱）区域的主要结构成分，并且了解机械刺激如何影响小梁骨结构有可能改善裂缝风险评估和预防裂缝风险策略。 工作中产生的方法将通过整合到题为“骨骼力学”的研究生课程中增强教学。 此外，作为该项目的一部分，调查人员将为来自代表性不足的小组的本科生和研究生的年度研讨会做出贡献，目的是帮助学生为研究生院和科学和工程学的职业做好准备。 该项目中的科学工作将通过科学期刊的科学会议和出版物的演讲来传播。