Switchable polymer interfaces for bottom-up stimulation of mamalian cells

用于自下而上刺激哺乳动物细胞的可切换聚合物接口

• 批准号: 200926410
• 负责人: Dr. Klaus-Jochen Eichhorn
• 金额: --
• 依托单位: Leibniz-Institut für Polymerforschung Dresden (IPF)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/200926410?language=en
• 关键词: Switchable; polymer; interfaces; bottom; up

The ultimate goal of this project is to design and characterize a responsive thin polymer film platform comprised of functionalized mixed polymer brushes for the stimuli-triggered exposure of functional molecules to the bioengineered interfaces of mammalian cells. The project is within the framework of already established cooperation between Clemson University, Clarkson University, Dresden Technical University, Leibniz-Institute for Polymer Research Dresden, University of Göttingen, and Leibniz-Institute for Analytical Sciences (in Berlin) laboratories consisting of experts in the polymer, surface, and materials science. To accomplish the proposal objectives we extend the expertise of our research team by adding a bioengineer from the University of California in Davis, whose expertise relates to designing biological interfaces for cell cultivation and differentiation.

该项目的最终目标是设计和表征一个由功能化混合聚合物刷组成的响应性聚合物薄膜平台，用于刺激触发的功能分子暴露于哺乳动物细胞的生物工程界面。该项目是在克莱姆森大学、克拉克森大学、德累斯顿技术大学、德累斯顿莱布尼茨聚合物研究所、Göttingen大学和柏林莱布尼茨分析科学研究所（由聚合物、表面和材料科学专家组成的实验室）已经建立的合作框架内进行的。为了完成提案的目标，我们增加了一名来自加州大学戴维斯分校的生物工程师，他的专业知识涉及设计细胞培养和分化的生物界面，从而扩展了我们研究团队的专业知识。

项目成果

Poly(N-isopropylacrylamide)-Based Mixed Brushes: A Computer Simulation Study.

• DOI: 10.1021/am5076309
• 发表时间: 2015-01
• 期刊: ACS applied materials & interfaces
• 影响因子: 9.5
• 作者: F. Léonforté;M. Müller

Functional Poly(N-isopropylacrylamide)/Poly(acrylic acid) Mixed Brushes for Controlled Manipulation of Nanoparticles

• DOI: 10.1021/acs.macromol.6b00535
• 发表时间: 2016-07
• 期刊: Macromolecules
• 影响因子: 5.5
• 作者: F. Léonforté;M. Müller

Probing carbonyl-water hydrogen-bond interactions in thin polyoxazoline brushes.

• DOI: 10.1116/1.4939249
• 发表时间: 2016-01
• 期刊: Biointerphases
• 影响因子: 2.1
• 作者: Annika Kroning;A. Furchner;Stefan Adam;Petra Uhlmann;Karsten Hinrichs

Morphology Modulation of Multicomponent Polymer Brushes in Selective Solvent by Patterned Surfaces

• DOI: 10.1021/ma502256p
• 发表时间: 2015-01-13
• 期刊: MACROMOLECULES
• 影响因子: 5.5
• 作者: Leonforte, F.;Mueller, M.
• 通讯作者: Mueller, M.