Design of new responsive materials based on functional polymer brushes for smart tuning and sensoring of proteins and particles adsorption

基于功能聚合物刷的新型响应材料设计，用于蛋白质和颗粒吸附的智能调节和传感

• 批准号: 24551434
• 负责人: Dr. Klaus-Jochen Eichhorn
• 金额: --
• 依托单位: Leibniz-Institut für Polymerforschung Dresden (IPF)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/24551434?language=en
• 关键词: Design; new; responsive; materials; based

of primary importance as well. A very intriguing task will be application of spectroscopic ellipsometry in the evaluation the nature of the bonding between proteins, nanoparticles and polymer films. The structural changes in the proteins upon adsorption will be accomplished by IR ellipsometry. At this point, the combined expertise of the partners is very promising, concerning the synthesis and characterization of mixed brushes, fine tuning interfacial interactions at the specially designed mixed brushes in an aqueous medium, performing reasonable experiments to evaluate adsorption efficiency at the interface, and characterization of the changes in the secondary structure and conformation of the adsorbing protein layer.

也是最重要的。一项非常有趣的任务是应用光谱椭圆光度术来评估蛋白质、纳米颗粒和聚合物薄膜之间的结合性质。吸附后蛋白质的结构变化将通过红外椭圆光度法完成。在这一点上，合作伙伴的综合专业知识非常有前途，涉及混合刷的合成和表征，在水介质中专门设计的混合刷上微调界面相互作用，进行合理的实验来评估界面的吸附效率，以及吸附蛋白质层的二级结构和构象变化的表征。