High Frequency Miniature PiezoPump For Ventricular Assist

用于心室辅助的高频微型压电泵项目摘要先天性心脏病每年影响成千上万的婴儿。这种疾病最具破坏性的亚型之一是单心室异常，其中婴儿出生时有一个功能心室而不是两个。虽然研究人员已经使用传统的电磁驱动心室辅助设备来帮助患者，但这些技术对于儿童来说过于笨重，并且由于无法在不损失功率密度的情况下小型化而受到限制。因此，该提议的前提是在液压泵中使用压电材料提供了传统电磁VAD的替代方案。拟议研究计划的新奇在于开发一种新型小型高频压电心脏辅助装置，可用作帮助单心室循环儿童的电源。这一建议的智力价值是在高频和小型泵组件的压电材料之间的关系的基本理解的发展。这里的挑战是在不直接接触血液的情况下有效地将能量从压电体传递到模拟人体循环。这项拟议研究的更广泛影响是工程师和医生之间的跨学科合作，以开发专为儿童和患者量身定制的设备。这项研究还为高中和大学中代表性不足的学生提供了一个与加州大学洛杉矶分校的教师和研究生进行研究和发展导师式关系的机会。

High Frequency Miniature PiezoPump for Ventricular AssistProject SummaryCongenital heart disease affects thousands of infants every year. One the most devastating subclasses of this disease are single ventricle abnormalities, in which infants are born with one functional ventricle instead two. Although researchers have used traditional electromagnetic driven ventricular assist devices to aide patients, these technologies are too bulky for children and are limited by their inability to be miniaturized without loss in power density. Thus, the premise of this proposal is that the use of piezoelectric materials in a hydraulic pump offers an alternative to traditional electromagnetic VADs. The novelty of the proposed research plan is the development of a novel small scale high frequency piezoelectric cardiac assist device that can be used as a power source to help children with single ventricle circulations. The intellectual merit of this proposal is the development of a fundamental understanding of the relationship between piezoelectric materials operated at high frequency and small-scale pump components. The challenge here is to effectively transfer energy from the piezoelectric to a simulated human circulation without direct blood contact. The broader impact of this proposed research is the interdisciplinary collaboration between engineers and doctors to develop devices specifically tailored for children and patients. This research also gives underrepresented students in high school and universities an opportunity to conduct research and develop mentor style relationships with faculty and graduate students at UCLA.