Nanostructured High Surface Area Sensor Systems for Enhanced Detection

用于增强检测的纳米结构高表面积传感器系统

• 批准号: 1102070
• 负责人: Sheila Grant
• 金额: $ 35.94万
• 依托单位: University of Missouri-Columbia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1102070&HistoricalAwards=false
• 关键词: Nanostructured; Surface; Area; Sensor; Systems

Objective: The objective of this program is to develop nanostructured coatings, nanoparticles, and plasmonic architectures that will lead to the development of fluorescence-based biosensor platforms for point-of-care diagnostics. Through the use of engineered plasmonic structures and nanostructured high surface area coatings, optimal field coupling to sensing elements will be achieved. Thermodynamic interaction occurring within nanoparticle?polymer composite films and the substrate interface will be investigated to achieve a high degree of control over the evolved nanostructures. These structures will be integrated with various plasmonic architectures, and the long range and short range surface plasmon polaritons will be studied. These unique sensor architectures will be validated via the detection of Botulinum and thrombin.Intellectual Merit: The intellectual merit is that a scientific study on integrative nanostructured sensing architectures will advance research in the area of point-of-care sensing technologies. The ability to control the entropic-enthalpic interplay between nanoparticles and polymer systems will enable ?bottom-up? fabrication of complex nanostructures. Such custom engineered thin films will serve as unique substrates for biological assays as well as novel optical coatings for plasmonic nanostructures enabling the detection of extremely low level fluorescence signals.Broader impacts: The broader impacts are the development of health-related diagnostic tools, in which the technology can be translated into diagnostics for national security, environment, energy, food safety, and manufacturing. The program includes an educational component involving recruitment of underrepresented students and hands-on learning opportunities in the field of plasmonics, nanostructure studies, and biosensing for secondary, undergraduates, and graduate students.

目的：该计划的目标是开发纳米结构涂层、纳米颗粒和等离子体系结构，从而开发基于荧光的生物传感器平台，用于医疗诊断。通过使用工程设计的等离子体结构和纳米结构的高比表面积涂层，将实现与传感元件的最佳场耦合。将研究纳米粒子-聚合物复合膜和基材界面之间的热力学相互作用，以实现对演变的纳米结构的高度控制。这些结构将与各种等离子体体系结构相结合，并将研究长程和短程表面等离子体激元。这些独特的传感器架构将通过检测肉毒杆菌和凝血酶进行验证。智能化的优点：智能化的优点是，对集成纳米结构传感架构的科学研究将促进护理点传感技术领域的研究。控制纳米粒子和聚合物体系之间的熵-热焓相互作用的能力将使？自下而上？制造复杂的纳米结构。这种定制的工程薄膜将作为生物分析的独特衬底，以及用于等离子体纳米结构的新型光学涂层，使其能够检测极低水平的荧光信号。广泛的影响：更广泛的影响是与健康相关的诊断工具的开发，在这些工具中，技术可以转化为国家安全、环境、能源、食品安全和制造的诊断。该计划包括一个教育部分，涉及招收代表人数不足的学生，以及为中学生、本科生和研究生提供等离子体、纳米结构研究和生物传感领域的实践学习机会。