Fluorescent Chemical Sensors for Bioactive Lipids

用于生物活性脂质的荧光化学传感器

• 批准号: 1112194
• 负责人: Timothy Glass
• 金额: $ 38.5万
• 依托单位: University of Missouri-Columbia
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1112194&HistoricalAwards=false
• 关键词: Fluorescent; Chemical; Sensors; Bioactive; Lipids

The Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division supports Professor Timothy Glass of the University of Missouri on a project focusing on the design and preparation of fluorescent sensors and receptors for various classes of biologically important lipids. These sensors are synthesized from tube-like hydrophobic receptor molecules that selectively recognize certain lipids by shape-selective interactions. Both macrocyclic 'closed tubes' and non-macrocyclic 'open tubes' are being explored. Because most lipids are embedded in a membrane or lipid compartment, the receptors are designed to extract the lipids from the membrane. The introduction of head-group binding units is a central focus of this project. This work lays a foundation for approaching many different problems in lipid recognition. Fundamental work on lipid recognition and sensing may eventually lead to the ability to selectively detect such lipids in humans. For example, such analyses can be used to test for oxidized phospholipids which have been found to be involved in atherosclerosis; or certain glycolipids which are know to be overproduced on the surface of cancerous cells. Moreover, students involved with this project are trained not only in the design and synthesis of novel compounds, but more broadly in methods of approaching biological problems from a chemical perspective.

化学系的大分子，超分子和纳米化学计划支持密苏里州大学的蒂莫西·格拉斯教授的一个项目，该项目专注于设计和制备各种生物重要脂质的荧光传感器和受体。这些传感器由管状疏水受体分子合成，通过形状选择性相互作用选择性识别某些脂质。大环“闭管”和非大环“开管”都在探索中。由于大多数脂质包埋在膜或脂质隔室中，因此受体被设计为从膜中提取脂质。引入头组绑定单元是该项目的中心焦点。这一工作为进一步研究脂质识别中的许多问题奠定了基础。 脂质识别和传感的基础工作可能最终导致选择性检测人类中的此类脂质的能力。例如，这种分析可以用于测试氧化磷脂，其已被发现参与动脉粥样硬化;或已知在癌细胞表面上过度产生的某些糖脂。此外，参与该项目的学生不仅在新化合物的设计和合成方面受到培训，而且更广泛地从化学角度处理生物问题的方法。