Gordon Research Conference:2011 Enzymes, Coenzymes and Metabolic Pathways July 10-15, 2011 Waterville, New Hampshire

戈登研究会议：2011 年酶、辅酶和代谢途径 2011 年 7 月 10-15 日新罕布什尔州沃特维尔

• 批准号: 1116515
• 负责人: James Stivers
• 金额: $ 0.5万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1116515&HistoricalAwards=false
• 关键词: Gordon; Research; Conference; 2011; Enzymes

Intellectual Merit:The Gordon Research Conference on Enzymes, Co-enzymes, and Metabolic Pathways will be held July 10-15, 2011 at the Waterville Valley Resort in Waterville, New Hampshire. There may be no other field of science that requires such a wide range of experimental approaches, theoretical frameworks and creative problem solving than the study of enzymes. The simple and fundamental question of "How do enzymes obtain their tremendous rate accelerations and specificities?" is simple to ask, but after over 100 years of study, is still enigmatic. Despite many areas of science being revolutionized by genomics, proteomics and metabolomic approaches, the understanding of enzyme mechanism and function still requires carefully designed integrated experiments that cover the spectrum of physics, chemistry, and biology. The practical importance of understanding enzymes is enormous because of their value as drug targets and industrial catalysts. Moreover, understanding and exploiting the processes of life requires that individual reactions be understood in the contexts of their metabolic pathways. It is at this level that life becomes genuinely more than the sum of the chemistry. The sessions and speakers in this conference will explore both fundamental and applied aspects of enzymology in the context of single enzymes and entire metabolic pathways.Broader Impacts:The Gordon Research Conference on Enzymes, Coenzymes, and Metabolic Pathways is one of the most influential meetings in the broad area of enzymology and has thrived for more than 60 years.This year's conference is co-chaired by a female enzymologist, and a significant proportion of the speakers and discussion leaders have been chosen from underrepresented groups. In addition, the eight short talks over the week will be populated with speakers from underrepresented groups. The unrushed, open format of the conference facilitates networking opportunities and intellectual development for graduate students and postdocs. In many important ways this unique gathering each year provides the seeds for growing this field of research and fostering the development of new investigators.

学术价值：戈登酶，辅酶和代谢途径研究会议将于2011年7月10日至15日在沃特维尔，新罕布什尔州沃特维尔山谷度假村举行。可能没有其他科学领域比酶的研究需要如此广泛的实验方法，理论框架和创造性的问题解决方案。简单而基本的问题是“酶如何获得其巨大的速率加速和特异性？“这个问题问起来很简单，但经过100多年的研究，仍然是个谜。尽管基因组学、蛋白质组学和代谢组学方法使许多科学领域发生了革命性的变化，但对酶机制和功能的理解仍然需要精心设计的综合实验，这些实验涵盖了物理学、化学和生物学。了解酶的实际重要性是巨大的，因为它们作为药物靶点和工业催化剂的价值。此外，理解和利用生命过程需要在其代谢途径的背景下理解个体反应。正是在这个层次上，生命才真正变得不仅仅是化学的总和。本次会议的主题和演讲者将在单一酶和整个代谢途径的背景下探讨酶学的基础和应用方面。更广泛的影响：酶、辅酶和代谢途径的戈登研究会议是酶学领域最有影响力的会议之一，已经蓬勃发展了60多年。今年的会议由一位女性酶学学家共同主持，很大一部分演讲者和讨论领导人来自代表性不足的群体。此外，本周的八次简短会谈将由代表性不足的团体的发言者参加。会议的不匆忙，开放的形式促进了研究生和博士后的网络机会和智力发展。在许多重要的方面，每年这种独特的聚会为发展这一研究领域和促进新研究人员的发展提供了种子。