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Collaborative Research: Dynamics of Morphogen Gradients

合作研究：形态发生梯度动力学

基本信息

批准号：
1119714
负责人：
Stanislav Shvartsman
金额：
$ 24.99万
依托单位：
Princeton University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2011
资助国家：
美国
起止时间：
2011-10-01 至 2014-09-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1119714&HistoricalAwards=false
关键词：
Collaborative Research Dynamics Morphogen Gradients

项目摘要

The project describes a series of theoretical and experimental studies of morphogen gradients, defined as the concentration fields of chemical substances that control spatial patterns of cell differentiation in developing tissues. Molecular studies of embryogenesis have identified morphogen gradients in systems as diverse as body axes specification in insects and patterning of mammalian neocortex. Current studies of morphogen gradients move in an increasingly quantitative direction and demand the development of a rigorous theoretical framework that can be used to interpret experimental results and guide systems-level analyses of pattern formation mechanisms. This project develops such a framework, emphasizing the dynamics of morphogen gradient formation. This research combines rigorous mathematical and computational analysis of a general class of reaction-diffusion models of morphogen gradient formation and application of these models to a specific pattern formation event in Drosophila embryo.Broader impacts of proposed work include the development of a general mathematical framework for a highly conserved biological process. One of the main outcomes of proposed activity is a set of analytical results that can be used for the back-of-the-envelope analysis of pattern formation dynamics in a wide range of developmental systems. The proposed theoretical and experimental studies go hand-in-hand with the development of educational program that provides interdisciplinary training in the emerging field of developmental systems biology.

该项目描述了形态梯度的一系列理论和实验研究，定义为控制发育组织中细胞分化空间模式的化学物质的浓度场。胚胎发生的分子研究已经确定了不同系统中的形态梯度，如昆虫的体轴规范和哺乳动物新皮层的图案化。目前形态梯度的研究越来越多地向定量方向发展，并要求发展一个严格的理论框架，可用于解释实验结果和指导系统水平的模式形成机制的分析。这个项目发展了这样一个框架，强调形态梯度形成的动力学。这项研究结合了对形态发生梯度形成的一般反应扩散模型的严格数学和计算分析，以及这些模型对果蝇胚胎中特定模式形成事件的应用。拟议工作的更广泛影响包括为高度保守的生物过程开发通用数学框架。拟议活动的主要成果之一是一套分析结果，可用于对各种发展系统中的模式形成动态进行粗略分析。拟议的理论和实验研究与教育计划的发展齐头并进，该计划在发展系统生物学的新兴领域提供跨学科培训。