CAREER: Quantitative Analysis of Morphogen Gradients in Developing Tissues

职业：发育组织中形态发生梯度的定量分析

• 批准号: 0448919
• 负责人: Stanislav Shvartsman
• 金额: $ 40万
• 依托单位: Princeton University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-15 至 2012-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0448919&HistoricalAwards=false
• 关键词: CAREER; Quantitative; Analysis; Morphogen; Gradients

0448919Shvartsman The proposed work aims to examine the fundamental mechanisms of cell communication and tissue development using the epidermal growth factor receptor (EGFR) as a model network and Drosophila as the model organism. Using mathematical modeling, genetic experiments, and genomic analyses, the Principal Investigator will quantify the spatial gradient of EGFR activation in vivo, characterize the genome-wide transcriptional response to this gradient, and analyze how it is modulated by feedback loops. Such work generally aims at elucidating how biological systems construct ordered structures using chemical and physical signals. The work is applicable to embryo development and tissue regeneration. An innovative undergraduate course entitled "Patterns of Biological Design" will be developed. This course will cover how key engineering concepts (e.g., feedback, redundancy, robustness) manifest in biological and more traditional chemical and electrical systems. An exchange program with the University of Puerto Rico at Mayaguez will also be established.

0448919Shvartsman拟议的工作旨在研究细胞通讯和组织发育的基本机制，使用表皮生长因子受体（EGFR）作为模型网络和果蝇作为模型生物。使用数学建模，遗传实验和基因组分析，主要研究者将量化体内EGFR激活的空间梯度，表征对该梯度的全基因组转录反应，并分析它如何被反馈回路调节。这些工作通常旨在阐明生物系统如何使用化学和物理信号构建有序结构。 这项工作适用于胚胎发育和组织再生。 将开发一门题为“生物设计模式”的创新本科课程。 本课程将涵盖关键工程概念（例如，反馈、冗余、鲁棒性）在生物和更传统的化学和电系统中显现。还将与马亚圭斯的波多黎各大学建立一个交流方案。