Progesterone, Vasopressin and Social Behavior in Adult Male Rats

黄体酮、加压素和成年雄性大鼠的社会行为

• 批准号: 1122074
• 负责人: Anthony Auger
• 金额: $ 40万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1122074&HistoricalAwards=false
• 关键词: Progesterone; Vasopressin; Social; Behavior; Adult

A functional role for progesterone and its receptor in female behavior and physiology is fairly well established; however, the data on progesterone and progestin receptor (PR) function in males are relatively sparse. Although there are only a few studies examining the action of progesterone in males, the results confirm an exciting yet understudied role for progesterone and/or the progestin receptor in adult male behavior and physiology. The goal of this project is to test the hypothesis that progesterone impairs social behavior, specifically social memory/recognition and recently collected preliminary data strongly support this hypothesis in a male rodent model. This research is valuable as it will develop a framework for understanding the role that progesterone plays in influencing social behavior (i.e., social recognition) in males, and provide new molecular targets, such as the underlying steroid /neuropeptide interactions and epigenetic mechanisms, for understanding how social recognition is regulated. These studies will also aid in the understanding of which neural pathways in the brain become compromised in some disease states in which one?s ability to socially recognize other individuals is impaired. The current project will also provide a valuable opportunity for education and dissemination of knowledge. The training provided is designed to give back to the community by engaging students from elementary to graduate school, as well as increase participation of women and students from underrepresented backgrounds in all aspects of experimental science. The data and techniques used to gain these data will be shared with the scientific community, as well as disseminated to the public.

孕酮及其受体在女性行为和生理中的功能作用已经相当明确;然而，关于孕酮和孕酮受体（PR）在男性中的功能的数据相对较少。虽然只有少数研究检查孕酮在男性中的作用，但结果证实了孕酮和/或孕酮受体在成年男性行为和生理中的令人兴奋但未充分研究的作用。 该项目的目标是检验孕酮损害社会行为，特别是社会记忆/识别的假设，最近收集的初步数据在雄性啮齿动物模型中强烈支持这一假设。这项研究很有价值，因为它将为理解孕酮在影响社会行为中的作用（即，社会识别），并提供新的分子靶点，如潜在的类固醇/神经肽相互作用和表观遗传机制，了解社会识别是如何调节的。这些研究也将有助于了解大脑中的哪些神经通路在某些疾病状态下受到损害，在哪一个？的能力，社会认识其他人受损。目前的项目还将为教育和传播知识提供一个宝贵的机会。 所提供的培训旨在通过吸引从小学到研究生院的学生来回馈社区，并增加妇女和来自代表性不足背景的学生对实验科学各个方面的参与。用于获取这些数据的数据和技术将与科学界分享，并向公众传播。