International Collaboration in Chemistry: Structure and dynamics of amino acids adsorbed on coinage metal surfaces

国际化学合作：吸附在造币金属表面的氨基酸的结构和动力学

• 批准号: 1124879
• 负责人: Barbara Hinch
• 金额: $ 40.42万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-10-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1124879&HistoricalAwards=false
• 关键词: International; Collaboration; Chemistry; Structure; dynamics

With the support of the Chemical Structure, Dynamics and Mechanisms Program, Professor Hinch and her coworkers in the Department of Chemistry and Chemical Biology at Rutgers University are using high resolution angular diffraction and time of flight analysis of thermal helium scattering to investigate structure, assembly and low energy molecule surface vibrations of adsorbed amino acids. This International Collaboration in Chemistry award includes a collaborator, Professor Stephen J. Jenkins at Cambridge University in the United Kingdom. His work is supported by EPSRC in the United Kingdom. The interactions of alanine, glycine and proline adsorbates with coinage metal surfaces are the focus of this research. These systems are believed to adsorb as carboxylate species and the amino groups may or may not undergo protonation. Information about chirality and possible racemization of adsorbed phases will be evident in the surface sensitive diffraction measurements. The real time kinetics of film assembly of these molecules on the surfaces, determined with this non destructive probe, will provide an understanding of the long- and short- range intermolecular interactions. In transitioning from low to high coverage regimes, changes in the discrete vibrational modes, and the effective masses of the scattering centers, will elucidate the significance of hydrogen bonding in these self assembled films. The low energy vibrational spectra are also to determine the influence of coadsorbed hydrogen levels in film stability, kinetics of assembly and surface diffusion and reaction mechanisms. Through collaboration with Professor Jenkins' group at Cambridge University, the Hinch group at Rutgers will also be able to utilize high-resolution low-temperature scanning probe techniques for studies of amino acid films. The international collaboration also offers a powerful computational capability and understanding of the multi-dimensional potential energy surfaces governing vibrational motion in simple adsorbed amino acids. A mutual objective is to image, simulate, and measure the dynamics within hydrogen bonding networks established in the amino acid films.This research will advance the understanding of the behavior of molecules adsorbed on surfaces. The knowledge obtained will implications for a variety of fields and applications, including chirally-specific sensors, enantioselective chemical synthesis, and possibly medical implant materials with improved biocompatibility. The research also has considerable workforce development benefits, as graduate and undergraduate students and post-doctoral associates will engage in a richly interdisciplinary research experience, which entails a variety of experimental techniques as well as theory and computation. The student experience will be further augmented by the international exchange aspects; extended visits by Rutgers and Cambridge group researchers to the partnering laboratory will provide invaluable experience with research environments beyond each participant's home institution.

在化学结构，动力学和机制计划的支持下，罗格斯大学化学和化学生物学系的Hinch教授和她的同事正在使用热氦散射的高分辨率角衍射和飞行时间分析来研究吸附氨基酸的结构，组装和低能分子表面振动。这个国际化学合作奖包括一个合作者，英国剑桥大学的斯蒂芬J.詹金斯教授。 他的工作得到了英国EPSRC的支持。 丙氨酸、甘氨酸和脯氨酸吸附物与钴金属表面的相互作用是本研究的重点。据信这些系统作为羧酸盐物质吸附，并且氨基可能经历或可能不经历质子化。手性和可能的外消旋吸附相的信息将是显而易见的，在表面敏感的衍射测量。用这种非破坏性探针测定的这些分子在表面上的膜组装的真实的时间动力学将提供对长距离和短距离分子间相互作用的理解。在过渡从低到高的覆盖范围制度，在离散的振动模式的变化，和散射中心的有效质量，将阐明这些自组装膜中的氢键的意义。 低能振动光谱也可以用来确定共吸附氢能级对薄膜稳定性、组装动力学和表面扩散以及反应机理的影响。通过与剑桥大学的詹金斯教授小组的合作，罗格斯大学的欣奇小组也将能够利用高分辨率低温扫描探针技术来研究氨基酸薄膜。 该国际合作还提供了强大的计算能力和对简单吸附氨基酸中控制振动运动的多维势能表面的理解。 一个共同的目标是成像，模拟和测量的氨基酸薄膜中建立的氢键网络内的动力学。这项研究将推进分子吸附在表面上的行为的理解。所获得的知识将影响到各种领域和应用，包括手性特异性传感器，对映选择性化学合成，并可能与改善生物相容性的医疗植入材料。 这项研究也有相当大的劳动力发展的好处，研究生和本科生和博士后助理将从事丰富的跨学科研究经验，这需要各种实验技术以及理论和计算。 学生的经验将通过国际交流方面进一步增强;罗格斯大学和剑桥大学研究人员对合作实验室的长期访问将为每个参与者的家庭机构之外的研究环境提供宝贵的经验。