BRIGE: Characterizing the Time-Dependent and Anisotropic Mechanical Properties of the Uterine Cervix with Micro and Nano Indentation

BRIGE：用微米和纳米压痕表征子宫颈的时间依赖性和各向异性机械特性

• 批准号: 1125670
• 负责人: Kristin Myers
• 金额: $ 17.5万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1125670&HistoricalAwards=false
• 关键词: BRIGE; Characterizing; Time; Dependent; Anisotropic

This Broadening Participation Research Initiation Grant in Engineering (BRIGE) award provides funding for the investigation of the mechanical properties of human cervical tissue and provides opportunities to raise the visibility of engineering science to female students. The research goal is to quantify cervical structure and material property relationships to determine how cervical tissue remodeling and mechanical properties influence each other during pregnancy. The cervical extracellular matrix (ECM) is responsible for maintaining tissue mechanical integrity and for regulating cell activity. The architecture of the collagen network and the interaction of the collagen fibers with its surroundings dictate the non-linear, time-dependent, and anisotropic material behavior of the tissue. This research aims to develop a micro and nanoindentation technique to account for the anisotropic and time-dependent mechanical behavior of cervical tissue and to develop finite element analysis tools to explore stress and strain behavior during indentation. This testing framework will guide the development of an appropriate constitutive model to generate descriptive material properties and will benefit future investigations of cervical tissue altered through disease, genetic manipulation, and biochemical alteration.The cervix is a mechanical barrier, retaining the fetus inside the uterus during pregnancy. The mechanical integrity of the cervix and the precise timing of tissue remodeling events during pregnancy are critical for a healthy gestation of the fetus. The research funded by this grant aims to characterize the mechanical behavior of human cervical tissue and to quantify how connective tissue alterations may influence cervical material properties. The goal is to develop appropriate experimental and analytical methodologies to account for the complex nature of the tissue. The research conducted in the PI's lab is dedicated to the advancement of women's health through scientific research, and through these efforts the PI further aims to attract and recruit female students to the engineering field through efforts at the high school, undergraduate, and graduate level.

这个扩大参与工程研究启动补助金（BRIGE）奖为人类子宫颈组织的机械性能的调查提供资金，并提供机会，以提高工程科学的知名度，以女学生。研究目标是量化宫颈结构和材料性能的关系，以确定宫颈组织重塑和机械性能如何在怀孕期间相互影响。宫颈细胞外基质（ECM）负责维持组织的机械完整性和调节细胞活性。胶原网络的结构和胶原纤维与其周围环境的相互作用决定了组织的非线性、时间依赖性和各向异性材料行为。本研究旨在开发一种微纳米压痕技术，以解释宫颈组织的各向异性和随时间变化的力学行为，并开发有限元分析工具，以探索压痕过程中的应力和应变行为。这个测试框架将指导一个适当的本构模型的发展，以产生描述性的材料属性，并将有利于未来的调查宫颈组织改变通过疾病，遗传操作，和生化alteration.The宫颈是一个机械屏障，保留在子宫内的胎儿在怀孕期间。宫颈的机械完整性和怀孕期间组织重塑事件的精确时间对于胎儿的健康妊娠至关重要。这项研究的目的是描述人类宫颈组织的力学行为，并量化结缔组织的改变如何影响宫颈材料的特性。目标是开发适当的实验和分析方法，以解释组织的复杂性质。在PI实验室进行的研究致力于通过科学研究促进妇女健康，通过这些努力，PI进一步旨在通过高中、本科和研究生一级的努力吸引和招募女生进入工程领域。