A self-assembled nano-array platform for membrane protein sensors and analytics

用于膜蛋白传感器和分析的自组装纳米阵列平台

• 批准号: 1134222
• 负责人: Shannon Servoss
• 金额: $ 33万
• 依托单位: University of Arkansas
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1134222&HistoricalAwards=false
• 关键词: self; assembled; nano; array; platform

1134222RoperIntellectual Merit: This NSF award by the Biosensing /CBET program supports work by Professors D. Keith Roper and Shannon Servoss at University of Arkansas is to self assemble a novel platform to detect and analyze membrane proteins. The platform consists of electromagnetically active arrays of nanorings in which lipid bilayers are stabilized by novel linkers to stabilize and test membrane proteins better than existing lipid vesicles. Electromagnetism interacting with concentrated electrons localized to the nanoring interface provides increased sensitivity relative to existing optical or electronic sensors. Supporting this study develops a sensitive, highthroughput platform to detect biomarkers to diagnose disease, test efficacy for therapeutic targets, and advance understanding of cell function.Broader Impacts: This study will educate two graduate students in active bio/nano photonics and peptidomimetics in an integrative multidisciplinary environment to fabricate and analyze nano scale devices and biomaterials. Its social impact includes introducing underrepresented undergraduates to STEM research in NSF REU programs. Results will incorporated into workshops to introduce K-12 students to engineering in interactive, hands; on experiments as part of a program sponsored by the College of Engineering. Its economic impact arises from possible applications of self; assembled electromagnetic biomaterials that enhance single; molecule microscopy and biosensing and become next generation opto electronic elements in microarrays and near; field optical microscopy.

1134222RoperIntellectual Merit：这项由生物传感/CBET项目颁发的国家科学基金会奖支持阿肯色大学教授D. Keith Roper和Shannon Servoss的工作，他们自组装了一个检测和分析膜蛋白的新平台。该平台由电磁活性纳米结构阵列组成，其中脂质双分子层通过新型连接物稳定，比现有的脂质囊泡更好地稳定和测试膜蛋白。电磁与纳米环界面上的集中电子相互作用，相对于现有的光学或电子传感器提供了更高的灵敏度。为了支持这项研究，开发了一个灵敏、高通量的平台来检测生物标志物，以诊断疾病，测试治疗靶点的疗效，并促进对细胞功能的理解。更广泛的影响：本研究将在一个整合多学科的环境中培养两名活性生物/纳米光子学和肽模拟学的研究生，以制造和分析纳米级器件和生物材料。它的社会影响包括向代表性不足的本科生介绍NSF REU项目中的STEM研究。结果将纳入研讨会，以互动的方式向K-12学生介绍工程；作为工程学院赞助的一个项目的一部分它的经济影响来自自我的可能应用；集成化电磁生物材料增强单一性；分子显微镜和生物传感成为下一代光电元件在微阵列和附近；野外光学显微镜。