A self-assembled nano-array platform for membrane protein sensors and analytics

用于膜蛋白传感器和分析的自组装纳米阵列平台

• 批准号: 1134222
• 负责人: Shannon Servoss
• 金额: $ 33万
• 依托单位: University of Arkansas
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1134222&HistoricalAwards=false
• 关键词: self; assembled; nano; array; platform

1134222RoperIntellectual Merit: This NSF award by the Biosensing /CBET program supports work by Professors D. Keith Roper and Shannon Servoss at University of Arkansas is to self assemble a novel platform to detect and analyze membrane proteins. The platform consists of electromagnetically active arrays of nanorings in which lipid bilayers are stabilized by novel linkers to stabilize and test membrane proteins better than existing lipid vesicles. Electromagnetism interacting with concentrated electrons localized to the nanoring interface provides increased sensitivity relative to existing optical or electronic sensors. Supporting this study develops a sensitive, highthroughput platform to detect biomarkers to diagnose disease, test efficacy for therapeutic targets, and advance understanding of cell function.Broader Impacts: This study will educate two graduate students in active bio/nano photonics and peptidomimetics in an integrative multidisciplinary environment to fabricate and analyze nano scale devices and biomaterials. Its social impact includes introducing underrepresented undergraduates to STEM research in NSF REU programs. Results will incorporated into workshops to introduce K-12 students to engineering in interactive, hands; on experiments as part of a program sponsored by the College of Engineering. Its economic impact arises from possible applications of self; assembled electromagnetic biomaterials that enhance single; molecule microscopy and biosensing and become next generation opto electronic elements in microarrays and near; field optical microscopy.

1134222 Roperintellectual Feerit：Biossysing /CBET计划的NSF奖支持D. Keith Roper教授和阿肯色大学的Shannon Servoss的工作，是为了自我组装一个新颖的平台来检测和分析膜蛋白。该平台由纳米菌的电磁活性阵列组成，其中脂质双层通过新颖的接头稳定，以比现有的脂质囊泡更好地稳定和测试膜蛋白。与现有的光学传感器或电子传感器相对于Nanoring界面的浓缩电子相互作用的电磁作用可提高灵敏度。支持这项研究开发了一个敏感的高通量平台，可检测生物标志物以诊断疾病，测试治疗靶标的功效并提高对细胞功能的理解。Broader的影响：这项研究将在积极的Biio/Nano光子学上教育两名研究生，并在整合性多学科环境中构建和分析nano scale and Nanano scale and nanano scale and nanano scale and nanano scale and nanano。它的社会影响包括将代表性不足的本科生引入NSF REU计划中的研究。结果将纳入研讨会，将K-12学生介绍给互动，手中的工程；作为工程学院赞助的计划的一部分，在实验中。它的经济影响来自自我的可能应用。组装的电磁生物材料增强了单个；分子显微镜和生物传感，并成为微阵列和附近的下一代光学电子元件；场光学显微镜。