Collaborative Research: Analytical Method Transfer - Development of Case Studies

协作研究：分析方法转移 - 案例研究的发展

• 批准号: 1141042
• 负责人: Marina Koether
• 金额: $ 4.52万
• 依托单位: Kennesaw State University Research and Service Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1141042&HistoricalAwards=false
• 关键词: Collaborative; Research; Analytical; Method; Transfer

In this collaborative project undergraduate students enrolled in senior-level analytical chemistry laboratory courses at St. John Fisher College and Kennesaw State University are creating two novel experiments that are being validated through Analytical Method Transfer (AMT). Students at one college develop the experimental method, standard operating procedures, and figures of merit (i.e., accuracy, precision, specificity, selectivity, sensitivity, repeatability, reproducibility, linearity, range, detection limit, quantitation limit, robustness, and ruggedness). The experiment is transferred to the partnering college to undergo method equivalency testing by students. The experiments involve the dissolution of pharmaceutical dosage forms with the development of dissolution curves (release rates). Using UV-Vis spectroscopy or HPLC methods, the students determine the concentration of the active pharmaceutical ingredient in the dissolution media. A statistical comparison of the figures of merit determines the success of the AMT. The transferred experiments and student-generated data are being developed into case studies that use POGIL exercises. The student learning outcomes related to the AMT are being assessed through a standard pre-test and post-test method using multiple choice and free-response questions. In addition, students at four other colleges are evaluating the developed POGIL activities but are not using instrumentation. The collected data will be used to determine whether the learning outcomes for students participating in a laboratory POGIL activity (with access to instrumentation) are equivalent to those for students participating in a classroom POGIL activity (with no access to instrumentation). Student interviews are being conducted to determine whether any learning gains in AMT may be attributed to the POGIL activities. The interview results provide contextual information allowing project staff to tailor the POGIL activities to the students' experiences. Site visits also are being used to evaluate the fidelity of the implementation of the POGIL activities by documenting variables such as adherence to project goals and use of effective POGIL. The findings from the project are being disseminated through publications and presentations.Intellectual Merit. The teaching of AMT places students at the forefront of the global learning environment in analytical chemistry. Students 1) use a new instrument, a dissolution tester, not currently available in most analytical chemistry laboratories, and 2) address the curriculum concept of AMT, which is conducted world-wide but not currently taught to undergraduates. This engages both students and faculty in the discovery of acceptance criteria for an AMT based on figures of merit.Broader Impact. This project is designed to facilitate adaptation of a new laboratory experiment at other sites and promotes a collaborative effort of an inter-institutional faculty-student partnership. The results are being disseminated broadly, helping to build a STEM education community. The technical skills of students are being broadened, enabling them to become competitive in the global market place.

在这个合作项目中，就读于圣约翰费舍尔学院和肯尼索州立大学高级分析化学实验室课程的本科生正在创建两个通过分析方法转移（AMT）进行验证的新实验。一所学院的学生开发实验方法、标准操作程序和品质因数（即，准确度、精密度、专属性、选择性、灵敏度、重复性、再现性、线性、范围、检测限、定量限、耐用性和耐用性）。实验被转移到合作学院，由学生进行方法等效性测试。这些实验涉及药物剂型的溶出度，并绘制溶出曲线（释放速率）。使用紫外-可见光谱或HPLC方法，学生确定溶出介质中活性药物成分的浓度。品质因数的统计比较决定了AMT的成功。转移的实验和学生生成的数据正在开发成使用POGIL练习的案例研究。目前正在通过采用多项选择和自由回答问题的标准前测和后测方法，评估与先进技术有关的学生学习成果。此外，其他四所学院的学生正在评估开发的POGIL活动，但没有使用仪器。收集的数据将用于确定学生参加实验室POGIL活动（使用仪器）的学习成果是否等同于学生参加课堂POGIL活动（无法使用仪器）。正在进行学生访谈，以确定在AMT的任何学习成果是否可归因于POGIL活动。访谈结果提供了背景信息，使项目工作人员能够根据学生的经验定制POGIL活动。还通过实地访问记录诸如遵守项目目标和使用有效的POGIL等变量，评价POGIL活动执行的忠实性。该项目的调查结果正在通过出版物和介绍会进行传播。AMT的教学使学生处于分析化学全球学习环境的最前沿。学生1）使用一种新的仪器，溶出度测试仪，目前大多数分析化学实验室都没有，2）解决AMT的课程概念，这是在世界范围内进行，但目前没有教本科生。这使学生和教师都参与到基于品质因数的AMT验收标准的发现中。该项目旨在促进在其他地点进行新的实验室实验，并促进机构间师生伙伴关系的合作努力。研究结果正在广泛传播，有助于建立一个STEM教育社区。学生的技术技能正在扩大，使他们能够在全球市场上具有竞争力。