Orientation in space and perception of earth-verticality in patients with Parkinson`s disease and Pisa syndrome.

帕金森病和比萨综合征患者的空间定向和地球垂直度感知。

• 批准号: 203077750
• 负责人: Dr. Judith Wagner
• 金额: --
• 依托单位: Instituto de Neurociencias
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/203077750?language=en
• 关键词: Orientation; space; perception; earth; verticality

With this study we plan to investigate orientation in space in patients with Parkinsons disease (PD) and Pisa syndrome (PS). Orientation in space involves the visual, somatosensory and vestibular system. Perception of earth-verticality can be investigated by determining the subjective visual vertical (SVV). SVV tilts are induced in normal subjects when tilted >60° to one side (A effect). Altered verticality perception is also the hallmark of the ocular tilt reaction (OTR), a syndrome caused by lesions of the otolithic pathway between the inner ear and the medial longitudinal fasciculus (riMLF). It is characterized by deviation of the SVV, head tilt, ocular torsion and skew deviation. PD encompasses perceptual deficits including visual, vestibular and proprioceptive information processing. Abnormal axial postures are also frequent findings in PD. One such disorder of posture is PS, characterized by lateral flexion of the spine. Preliminary results show an SVV tilt in PS patients. It is unknown if this SVV tilt in PS is due to the A-effect, given the inner roll-plane deviation of these patients or due to a primary perceptual dysfunction. Could PS be a manifestation of otolithic imbalance or of an asymmetric involvement of the riMLF? Do the alterations in perception of body schema and in the integration of somatosensory information change the OTR classic features to a body lateral deviation? How does dopaminergic medication affect these somatosensory and perceptual deficits? We plan to collect demographic and clinical data of the PD/PS population at the Institute of Neurosciences of the Favaloro Foundation, Buenos Aires, Argentina. These patients will be investigated for signs of an OTR, and the A-effect will be examined by determining the SVV in different degrees of body tilt (with and without dopaminergic stimulation) and compared to PD-patients without PS, PD-patients with lateral deviation not caused by PS, and healthy subjects.

通过这项研究，我们计划调查帕金森氏病(PD)和比萨综合征(PS)患者的空间定向。空间定向涉及视觉、躯体感觉和前庭系统。对地球垂直度的感知可以通过确定主观视觉垂直(SVV)来调查。当SVV向一侧倾斜60°时，正常受试者会诱发SVV倾斜(A效应)。垂直度感觉改变也是眼球倾斜反应(OTR)的标志，这是一种由内耳和内侧纵束(RiMLF)之间的耳石通路损伤引起的综合征。其特点是SVV偏斜、头部倾斜、眼球扭转和斜视。帕金森病包括知觉缺陷，包括视觉、前庭和本体感觉信息加工。轴位异常也是帕金森病常见的表现。一种这样的姿势障碍是PS，其特征是脊柱侧弯。初步结果显示PS患者存在SVV倾斜。目前尚不清楚PS中的SVV倾斜是由于A效应，考虑到这些患者的内侧滚动面偏差，还是由于原发知觉障碍。PS可能是耳石失衡或rMLF不对称受累的表现吗？躯体图式知觉和躯体感觉信息整合的变化是否会将OTR的经典特征改变为身体侧向偏差？多巴胺能药物如何影响这些躯体感觉和知觉缺陷？我们计划在阿根廷布宜诺斯艾利斯Favaloro基金会的神经科学研究所收集PD/PS人口的人口学和临床数据。这些患者将被调查是否有OTR的迹象，A效应将通过测定不同程度的身体倾斜(有或没有多巴胺能刺激)的SVV来检验，并与PD-没有PS的患者、PD-非PS引起的侧偏的患者以及健康受试者进行比较。