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Effects of cholinergic axonal plasticity on spatial orientation

胆碱能轴突可塑性对空间定向的影响

基本信息

批准号：
9590726
负责人：
DOUGLAS WALLACE
金额：
$ 40.82万
依托单位：
NORTHERN ILLINOIS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-15 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9590726
关键词：
Adult Age Aging-Related Process Alzheimer&apos s Disease Animal Model Animals Antibodies Attenuated Auditory Behavioral Brain Caregivers Chronic Cognitive deficits Cues Deafferentation procedure Dementia Development Diagnosis Disease Disorientation Effectiveness Environment Foundations Goals Growth Factor Gene Health care facility Hippocampus (Brain)Home environment Human Immunotherapy Impairment Injury Intervention Learning Left Life Long-Term Care Modality Modeling Motor Movement NGFR Protein Neighborhoods Nerve Growth Factors Neurodegenerative Disorders Neuronal Plasticity Nociception Participant Pathology Patients Performance Phase I Clinical Trials Population Process Proprioception Public Health Rattus Research Resources Rodent Model Role Science Signal Pathway Signal Transduction Societies Source Space Perception Spinal cord injury Stroke Structure System Techniques Therapeutic Intervention Therapeutic Uses Time Training Transgenic Mice Traumatic Brain Injury Visual Work age effect age related aged analog automobile accident basal forebrain basal forebrain cholinergic neurons career cholinergic demographics economic impact effective therapy experience experimental study falls gene therapy graduate student improved information processing kinematics nervous system disorder neuropathology nonhuman primate novel novel therapeutic intervention novel therapeutics prevent retrograde transport senescence septohippocampal translational model undergraduate student

项目摘要

Project Summary/Abstract Neurodegenerative disorders can produce significant impairments in a patient’s ability to maintain spatial orientation. The current changing age structure of the US population in combination with lack of effective treatments for neurodegenerative disorders presents serious challenges for society in the management of these patients. Evaluating novel therapies for neurodegenerative disorders will depend on identifying an appropriate animal model of spatial orientation. Rats, like humans, use environmental and self-movement cues to maintain spatial orientation. My research has focused on developing tasks for rats that dissociate the use of either source of information. The basal forebrain cholinergic projections undergoes significant degeneration during the progression of Dementia of the Alzheimer's Type. The experiments outlined in this proposal represent the next step in investigating the potential of enhancing neuroplasticity to improve cognitive deficits associated with pathology in the basal forebrain cholinergic neurons. One goal of the proposal examines whether anti-Nogo-A immunotherapy is sufficient to promote neuroplasticity basal forebrain cholinergic neurons in adult and senescent rats. Another goal is to evaluate the extent that enhanced neuroplasticity at either age is sufficient to ameliorate self-movement cue processing deficits. A final goal is to provide training experiences for undergrad and graduate students that will establish a foundation to pursue a career in the biomedical sciences. The results of these studies will advance our understanding of the effects of aging on spatial orientation and evaluate the potential of anti-Nogo-A immunotherapies as a novel intervention for neurodegenerative disorders.

项目概要/摘要神经退行性疾病会对患者维持空间能力的能力产生严重损害方向。当前美国人口年龄结构的变化以及缺乏有效的神经退行性疾病的治疗给社会管理带来了严峻的挑战这些病人。评估神经退行性疾病的新疗法将取决于确定适当的空间定向动物模型。老鼠和人类一样，利用环境和自我运动的线索以保持空间方向。我的研究重点是为老鼠开发任务，使它们与使用任一信息来源。基底前脑胆碱能投射经历显着退化在阿尔茨海默氏型痴呆的进展过程中。本提案中概述的实验代表了研究增强神经可塑性以改善认知缺陷的潜力的下一步与基底前脑胆碱能神经元的病理学相关。该提案的目标之一是审查抗Nogo-A免疫疗法是否足以促进基底前脑胆碱能神经可塑性成年和衰老大鼠的神经元。另一个目标是评估神经可塑性增强的程度任何一个年龄都足以改善自我运动线索处理缺陷。最终目标是提供培训为本科生和研究生提供经验，为他们在该领域的职业生涯奠定基础生物医学科学。这些研究结果将加深我们对衰老影响的理解空间定位并评估抗 Nogo-A 免疫疗法作为新型干预措施的潜力神经退行性疾病。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

DOI：
10.1016/j.beproc.2022.104713
发表时间：
2022-09
期刊：
BEHAVIOURAL PROCESSES
影响因子：
1.3
作者：
Oltmanns, J. R. Osterlund;Schaeffer, E. A.;Blackwell, A. A.;Lake, R. I.;Einhaus, R. M.;Kartje, G. L.;Wallace, D. G.
通讯作者：
Wallace, D. G.