RUI: Investigating Hox gene regulation of paired appendage patterning in the basal actinopterygian, Polyodon
RUI:研究基底放线翅目、多齿兽中配对附属物模式的 Hox 基因调控
基本信息
- 批准号:1144965
- 负责人:
- 金额:$ 40万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-03-01 至 2017-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Terrestrial (land living) vertebrates possess a specialized region of their appendages called the autopod (hands & feet; fingers & toes) which are not present in their aquatic fish ancestors. Variation in key genes that form the autopod generate the diversity of crawling, flying, and swimming adaptations we see in nature, but also explain common forms of congenital birth defects seen in human hands and feet. Previously, this laboratory discovered that genes involved in autopod formation, called Hox genes, are active in the fins of a primitive living fish, the North American paddlefish Polyodon spathula. This fish does not have an autopod region, nor did it evolve from an ancestor that had an autopod. Why then, do paddlefish have these genes and what is their function? To address these questions, these investigators are using modified versions of these genes designed to either shut down gene function or amplify it above normal levels within the developing fins of embryonic paddlefish. These results should reveal the normal function of these genes, and interpret the results of abnormal gene expression in comparison to data from human and mouse birth defects. Initial results demonstrate a pattern of loss of skeletal structures that links specific Hox genes to the formation of specific portions of the fin, in a manner similar to humans and mice. These results will provide significant insights into autopod formation that will answer both evolutionary questions and contribute to clinical approaches for addressing congenital autopod birth defects in humans. In addition, undergraduates at Kennesaw State will comprise the core of this research, providing numerous students with research experience to prepare them for careers in medicine and the biological sciences.
陆生脊椎动物有一个特殊的附属物区域,叫做自足(手和脚;手指和脚趾),这是它们的水生鱼类祖先所没有的。形成自足体的关键基因的变异产生了我们在自然界中看到的爬行、飞行和游泳适应的多样性,但也解释了人类手脚常见的先天性缺陷。此前,该实验室发现,在一种原始鱼类——北美白鲟(Polyodon spathula)的鳍中,参与自食体形成的基因(称为Hox基因)很活跃。这种鱼没有自足区,也不是从有自足区的祖先进化而来的。那么,为什么白鲟有这些基因,它们的功能是什么?为了解决这些问题,这些研究人员正在使用这些基因的修改版本,旨在关闭基因功能或将其扩增到高于胚胎白鲟发育鳍的正常水平。这些结果将揭示这些基因的正常功能,并将异常基因表达的结果与人类和小鼠出生缺陷的数据进行比较。最初的结果显示了一种骨骼结构的缺失模式,这种模式将特定的Hox基因与鳍的特定部分的形成联系起来,其方式与人类和老鼠相似。这些结果将为自体细胞形成提供重要的见解,这将回答进化问题,并有助于解决人类先天性自体细胞出生缺陷的临床方法。此外,肯尼索州立大学的本科生将构成这项研究的核心,为众多学生提供研究经验,为他们在医学和生物科学领域的职业生涯做好准备。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Fin-fold development in paddlefish and catshark and implications for the evolution of the autopod
- DOI:10.1098/rspb.2016.2780
- 发表时间:2017-05
- 期刊:
- 影响因子:0
- 作者:Frank J. Tulenko;James L. Massey;E. Holmquist;Gabriel Kigundu;Sarah Thomas;Susan M E Smith;S. Mazan;Marcus C. Davis
- 通讯作者:Frank J. Tulenko;James L. Massey;E. Holmquist;Gabriel Kigundu;Sarah Thomas;Susan M E Smith;S. Mazan;Marcus C. Davis
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Marcus Davis其他文献
Sa1522 – Galanin Enhances Hepatic Fibrosis in Mdr2 Knockout Mice Via Co-Ordinate Activation of Galanin Receptors on Cholangiocytes and Hepatic Stellate Cells
- DOI:
10.1016/s0016-5085(19)40072-3 - 发表时间:
2019-05-01 - 期刊:
- 影响因子:
- 作者:
Marcus Davis;Anca Petrescu;Stephanie Grant;Gabriel Frampton;Elaina Williams;Natalie Parks;Hanna L. Blaney;Matthew McMillin;Sharon DeMorrow - 通讯作者:
Sharon DeMorrow
Ultrasound diagnosis of breast implant rupture: beware the atypical presentation and interpret with care
乳房假体破裂超声诊断:警惕非典型表现,谨慎解读
- DOI:
- 发表时间:
2011 - 期刊:
- 影响因子:0.5
- 作者:
Marcus Davis;S. Gore;S. Papanastasiou - 通讯作者:
S. Papanastasiou
Conserved mechanisms in vertebrate A/P appendage patterning
- DOI:
10.1016/j.ydbio.2006.04.202 - 发表时间:
2006-07-01 - 期刊:
- 影响因子:
- 作者:
Randall Dahn;Marcus Davis;Neil Shubin - 通讯作者:
Neil Shubin
Northward range expansion of the invasive coral (Tubastraea tagusensis) in the southwestern Atlantic
西南大西洋入侵珊瑚(Tubastraea tagusensis)范围向北扩张
- DOI:
10.1007/s12526-016-0623-x - 发表时间:
2018 - 期刊:
- 影响因子:1.6
- 作者:
Marcelo Oliveira Soares;Marcus Davis;Pedro Bastos Macêdo Carneiro - 通讯作者:
Pedro Bastos Macêdo Carneiro
Sa1519 – Neuronal Ablation of Fxr Signaling Attenuates the Dysregulation of Galanin and Neuropeptide Y Resulting in Improved Liver Pathology During Cholestasis
- DOI:
10.1016/s0016-5085(19)40069-3 - 发表时间:
2019-05-01 - 期刊:
- 影响因子:
- 作者:
Hanna L. Blaney;Stephanie Grant;Elaina Williams;Gabriel Frampton;Anca Petrescu;Marcus Davis;Matthew McMillin;Sharon DeMorrow - 通讯作者:
Sharon DeMorrow
Marcus Davis的其他文献
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{{ truncateString('Marcus Davis', 18)}}的其他基金
RUI: Evolutionary origins of the vertebrate paired appendage gene regulatory network
RUI:脊椎动物配对附肢基因调控网络的进化起源
- 批准号:
1853949 - 财政年份:2018
- 资助金额:
$ 40万 - 项目类别:
Standard Grant
RUI: Evolutionary origins of the vertebrate paired appendage gene regulatory network
RUI:脊椎动物配对附肢基因调控网络的进化起源
- 批准号:
1656464 - 财政年份:2017
- 资助金额:
$ 40万 - 项目类别:
Standard Grant
MRI: Acquisition of a Confocal Microscope for Multidisciplinary Research
MRI:购买共焦显微镜进行多学科研究
- 批准号:
1229237 - 财政年份:2012
- 资助金额:
$ 40万 - 项目类别:
Standard Grant
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