SBIR Phase II: Electronic Allergy Diagnostics: Photo-Immobilization as a General Strategy for Attaching Structurally and Compositionally Diverse Ligands onto a Single Support

这个小型企业创新研究（SBIR）第二阶段项目旨在为药物，食物和环境过敏创造更好的诊断测试。 如果成功的话，它将通过在医生那里进行快速评估，在过敏性疾病的临床诊断中产生变革性的影响。这项研究的更广泛的影响是下一代诊断设备的发展。 这些设备将使许多不同的条件和疾病的诊断，只有一个小滴血，对一个医生？的办公室。 从血液中进行疾病诊断通常需要从患者的静脉中采集血液样本，通常是一个或多个装满血液的试管。的手臂，并送往临床实验室。 这对患者来说是不舒服的，需要他们等待数天的结果，是昂贵的，并且比病毒基因组学正在开发的方法更不安全，因为必须运输和处理大量的血液。 病毒基因组学平台将只使用一滴血，并将提供结果，而病人仍然在医生？的办公室。 这种诊断测试的工作原理类似于糖尿病患者用来监测血糖的血糖监测仪，但在可以进行的测试类型方面更加灵活。除了过敏诊断之外，所提出的诊断平台还将应用于影响我们健康的许多其他领域，例如自身免疫性疾病、传染病和癌症的诊断。

This Small Business Innovation Research (SBIR) Phase II project aims to create better diagnostic testing for drug, food, and environmental allergies. If successful, it would be transformative in the clinical diagnosis of allergy diseases by enabling rapid evaluation at the doctor?s office in a format that is significantly preferable to skin-prick or challenge testing.The broader impacts of this research are the development of next generation diagnostic devices. These devices will enable the diagnosis of many different conditions and diseases with just a small drop of blood, right in a doctor?s office. Disease diagnosis from blood often requires that the blood sample, typically one or more test tubes full of blood, be taken from a vein in a patient?s arm and sent to a clinical laboratory. This is uncomfortable for the patient, requires them to wait days for results, is expensive, and is less safe than the approach being developed by Virogenomics because a large amount of blood that must be transported and handled. The Virogenomics platform will use just a drop of blood and will provide results while the patient is still in the doctor?s office. This diagnostic test works similar to the blood-glucose monitors diabetics use to monitor their blood sugar but is much more flexible in regards to the types of tests that can be done. In addition to allergy diagnosis, the proposed diagnostic platform would have application in many other fields that affect our health, such as diagnostics for autoimmune diseases, infectious disease and cancer.