SBIR Phase II: Intraoperative Detection and Ablation of Microscopic Residual Cancer in the Tumor Bed
SBIR II 期:术中检测并消融瘤床中的微小残留癌
基本信息
- 批准号:1152489
- 负责人:
- 金额:$ 49.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-04-15 至 2017-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This Small Business Innovation Research (SBIR) Phase II project is aimed at developing a handheld system that a cancer surgeon uses to detect and eliminate microscopic residual cancer in the tumor bed after gross resection of the tumor. An integrated laser ablation system instantly removes the cancer cells identified by the imaging system during surgery, eliminating the need for repeat surgery. Effective resection of cancer is often difficult because of the need to spare essential tissue (blood vessels, nerves, brain) adjacent to the tumor and the lack of visual resolution of the tumor bed during manual resection. The integrated laser ablation system developed in Phase II will enhance the surgical technique by quickly and precisely eliminating residual cancer cells in the tumor bed. The objective of Phase II is to deliver a system ready for clinical trials, which includes: increasing the ablation speed, developing a larger field of view, and demonstrating efficacy in animal studies. After completion of this program, Lumicell will validate the performance of the novel system in human clinical trials.The broader impact/commercial potential of this project stems from improvements in patient care and reduction of healthcare costs. Currently, around 50% of breast cancer patients and 35% of sarcoma patients require second tumor de-bulking surgeries because a final pathology report returns days after the initial surgery indicating that residual cancerous cells have been left within the patient. Furthermore, 25% of the final pathology reports do not detect residual cancer cells due to sampling errors fundamentally inherent in the process. Thus, most patients require subsequent medical therapy including additional radiation or chemotherapy treatment to prevent cancer recurrence and metastasis stemming from residual cancer cells. The system is designed to find and destroy residual cancer cells in real-time at a single cell level. Tumors adjacent to critical nerve or brain tissue are particularly difficult and a laser therapy guided by the proposed imaging system would allow the surgeon to thoroughly eradicate cancer cells with minimal added work and no adverse effect on surrounding tissue. Lumicell's novel single cell imaging device combined with focused laser ablative therapy will have a significant impact on preventing second surgeries and subsequent medical therapy resulting in significant healthcare cost savings and improved patient care.
该小型企业创新研究(SBIR)第二阶段项目旨在开发一种手持式系统,癌症外科医生使用该系统在肿瘤大体切除后检测和消除肿瘤床中的微观残留癌症。集成的激光消融系统可在手术过程中立即去除成像系统识别的癌细胞,无需重复手术。 由于需要保留邻近肿瘤的重要组织(血管、神经、脑)以及手动切除过程中缺乏对肿瘤床的视觉分辨率,因此癌症的有效切除通常是困难的。第二阶段开发的集成激光消融系统将通过快速精确地消除肿瘤床中的残留癌细胞来提高手术技术。 第二阶段的目标是提供一个准备好进行临床试验的系统,包括:提高消融速度,开发更大的视野,并在动物研究中证明疗效。 该项目完成后,Lumicell将在人体临床试验中验证新系统的性能。该项目的更广泛影响/商业潜力源于改善患者护理和降低医疗成本。 目前,大约50%的乳腺癌患者和35%的肉瘤患者需要第二次肿瘤减瘤手术,因为最终病理报告在初次手术后几天返回,表明残留的癌细胞已留在患者体内。 此外,25%的最终病理学报告没有检测到残留的癌细胞,这是由于该过程中固有的采样误差。因此,大多数患者需要后续的药物治疗,包括额外的放射或化疗治疗,以防止癌症复发和残留癌细胞引起的转移。 该系统旨在在单细胞水平上实时发现和破坏残留的癌细胞。 邻近关键神经或脑组织的肿瘤特别困难,并且由所提出的成像系统引导的激光治疗将允许外科医生以最小的额外工作彻底根除癌细胞,并且对周围组织没有不利影响。 Lumicell的新型单细胞成像设备与聚焦激光消融治疗相结合,将对防止二次手术和后续药物治疗产生重大影响,从而显著节省医疗成本并改善患者护理。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
David Lee其他文献
Incidence of factor XII deficiency in critically ill patients with a prolonged activated partial thromboplastin time: a prospective observational study
活化部分凝血活酶时间延长的危重患者因子 XII 缺乏的发生率:一项前瞻性观察研究
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:1.1
- 作者:
Lipi Mishra;David Lee;Kwok M. Ho - 通讯作者:
Kwok M. Ho
Big city bats: Species-specific effects of the urban matrix on forearm length and fat stores of bats in the West Midlands, United Kingdom (Chiroptera: Vespertilionidae)
大城市蝙蝠:城市基质对英国西米德兰兹蝙蝠前臂长度和脂肪储存的物种特异性影响(翼手目:Vespertilionidae)
- DOI:
10.37520/lynx.2023.005 - 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Morgan Hughes;Scott K. Brown;Denise Foster;David Lee;Tamar Redfern;Simon Maddock;Christopher H. Young - 通讯作者:
Christopher H. Young
A Developmental Study on Types and Frequency Distribution of Short Apneas (3 to 15 Seconds) in Term and Preterm Infants
足月儿和早产儿短时呼吸暂停(3 至 15 秒)类型和频率分布的发育研究
- DOI:
10.1203/00006450-198709000-00021 - 发表时间:
1987 - 期刊:
- 影响因子:3.6
- 作者:
David Lee;R. Caces;K. Kwiatkowski;D. Cates;H. Rigatto - 通讯作者:
H. Rigatto
Meaning makers make it: Ambivalence about ambiguity in academic discourse
意义创造者做到了:学术话语中模棱两可的矛盾心理
- DOI:
- 发表时间:
2007 - 期刊:
- 影响因子:0
- 作者:
David Lee - 通讯作者:
David Lee
Multi-Hyb: A Hybrid Algorithm for Solving DisCSPs with Complex Local Problems
Multi-Hyb:一种用于解决具有复杂局部问题的 DisCSP 的混合算法
- DOI:
10.1109/wi-iat.2009.181 - 发表时间:
2009 - 期刊:
- 影响因子:0
- 作者:
David Lee;I. Arana;Hatem Ahriz;K. Hui - 通讯作者:
K. Hui
David Lee的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('David Lee', 18)}}的其他基金
HSI Implementation and Evaluation Project: Scaling and Extending Exploratory Reading Groups to Strengthen Computing Pathways
HSI 实施和评估项目:扩大和扩展探索性阅读小组以加强计算途径
- 批准号:
2414332 - 财政年份:2024
- 资助金额:
$ 49.42万 - 项目类别:
Continuing Grant
Scaling Experiential, Community-Engaged Learning using Micro-Role Based Curricula
使用基于微角色的课程扩展体验式社区参与学习
- 批准号:
2236055 - 财政年份:2023
- 资助金额:
$ 49.42万 - 项目类别:
Standard Grant
SBIR Phase I: Manufacturing of gallium nitride (GaN) membranes for efficient thermal management
SBIR 第一阶段:制造氮化镓 (GaN) 膜以实现高效热管理
- 批准号:
2135112 - 财政年份:2022
- 资助金额:
$ 49.42万 - 项目类别:
Standard Grant
Quantum phenomena in condensed atomic and molecular hydrogen
凝聚原子和分子氢中的量子现象
- 批准号:
2104756 - 财政年份:2021
- 资助金额:
$ 49.42万 - 项目类别:
Continuing Grant
Improving Undergraduate Computer Science Education via Reading Group Networks
通过阅读小组网络改善本科计算机科学教育
- 批准号:
1807388 - 财政年份:2018
- 资助金额:
$ 49.42万 - 项目类别:
Standard Grant
Studies of Atomic Hydrogen Contained in Solid Molecular Hydrogen Isotopes
固体分子氢同位素中所含原子氢的研究
- 批准号:
1707565 - 财政年份:2017
- 资助金额:
$ 49.42万 - 项目类别:
Standard Grant
Materials World Network: Quantum Phenomena in Atomic Hydrogen Stabilized in Solid Molecular Hydrogen
材料世界网:固体分子氢中稳定的原子氢的量子现象
- 批准号:
1209255 - 财政年份:2012
- 资助金额:
$ 49.42万 - 项目类别:
Continuing Grant
SBIR Phase I: Intraoperative Detection and Ablation of Microscopic Residual Cancer in the Tumor Bed
SBIR 第一阶段:术中检测并消融瘤床中的微小残留癌
- 批准号:
1046761 - 财政年份:2011
- 资助金额:
$ 49.42万 - 项目类别:
Standard Grant
Quantum Phenomena in Systems Containing Matrix Isolated Atomic Free Radicals
含有基质隔离原子自由基的系统中的量子现象
- 批准号:
0504683 - 财政年份:2005
- 资助金额:
$ 49.42万 - 项目类别:
Continuing grant
ICER Midwest Workshop: Preparing IT Graduates for 2010 and Beyond
ICER 中西部研讨会:为 2010 年及以后的 IT 毕业生做好准备
- 批准号:
0548403 - 财政年份:2005
- 资助金额:
$ 49.42万 - 项目类别:
Standard Grant
相似国自然基金
Baryogenesis, Dark Matter and Nanohertz Gravitational Waves from a Dark
Supercooled Phase Transition
- 批准号:24ZR1429700
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
ATLAS实验探测器Phase 2升级
- 批准号:11961141014
- 批准年份:2019
- 资助金额:3350 万元
- 项目类别:国际(地区)合作与交流项目
地幔含水相Phase E的温度压力稳定区域与晶体结构研究
- 批准号:41802035
- 批准年份:2018
- 资助金额:12.0 万元
- 项目类别:青年科学基金项目
基于数字增强干涉的Phase-OTDR高灵敏度定量测量技术研究
- 批准号:61675216
- 批准年份:2016
- 资助金额:60.0 万元
- 项目类别:面上项目
基于Phase-type分布的多状态系统可靠性模型研究
- 批准号:71501183
- 批准年份:2015
- 资助金额:17.4 万元
- 项目类别:青年科学基金项目
纳米(I-Phase+α-Mg)准共晶的临界半固态形成条件及生长机制
- 批准号:51201142
- 批准年份:2012
- 资助金额:25.0 万元
- 项目类别:青年科学基金项目
连续Phase-Type分布数据拟合方法及其应用研究
- 批准号:11101428
- 批准年份:2011
- 资助金额:23.0 万元
- 项目类别:青年科学基金项目
D-Phase准晶体的电子行为各向异性的研究
- 批准号:19374069
- 批准年份:1993
- 资助金额:6.4 万元
- 项目类别:面上项目
相似海外基金
SBIR Phase II: Innovative Glass Inspection for Advanced Semiconductor Packaging
SBIR 第二阶段:先进半导体封装的创新玻璃检测
- 批准号:
2335175 - 财政年份:2024
- 资助金额:
$ 49.42万 - 项目类别:
Cooperative Agreement
SBIR Phase II: Intelligent Language Learning Environment
SBIR第二阶段:智能语言学习环境
- 批准号:
2335265 - 财政年份:2024
- 资助金额:
$ 49.42万 - 项目类别:
Cooperative Agreement
SBIR Phase II: FlashPCB Service Commercialization and AI Component Package Identification
SBIR第二阶段:FlashPCB服务商业化和AI组件封装识别
- 批准号:
2335464 - 财政年份:2024
- 资助金额:
$ 49.42万 - 项目类别:
Cooperative Agreement
SBIR Phase II: Thermally-optimized power amplifiers for next-generation telecommunication and radar
SBIR 第二阶段:用于下一代电信和雷达的热优化功率放大器
- 批准号:
2335504 - 财政年份:2024
- 资助金额:
$ 49.42万 - 项目类别:
Cooperative Agreement
SBIR Phase II: Innovative Two-Phase Cooling with Micro Closed Loop Pulsating Heat Pipes for High Power Density Electronics
SBIR 第二阶段:用于高功率密度电子产品的创新两相冷却微闭环脉动热管
- 批准号:
2321862 - 财政年份:2024
- 资助金额:
$ 49.42万 - 项目类别:
Cooperative Agreement
SBIR Phase II: Sodium-Based Solid-State Batteries for Stationary Energy Storage
SBIR第二阶段:用于固定储能的钠基固态电池
- 批准号:
2331724 - 财政年份:2024
- 资助金额:
$ 49.42万 - 项目类别:
Cooperative Agreement
SBIR Phase II: A mesh-free, sling-free, minimally invasive treatment for stress urinary incontinence in women
SBIR II 期:无网、无吊带的微创治疗女性压力性尿失禁
- 批准号:
2233106 - 财政年份:2024
- 资助金额:
$ 49.42万 - 项目类别:
Cooperative Agreement
SBIR Phase II: Zero Trust Solution for Precision Medicine and Precision Health Data Exchanges
SBIR 第二阶段:精准医疗和精准健康数据交换的零信任解决方案
- 批准号:
2226026 - 财政年份:2024
- 资助金额:
$ 49.42万 - 项目类别:
Cooperative Agreement
SBIR Phase II: Computer-based co-reading for students with reading disabilities
SBIR 第二阶段:为有阅读障碍的学生提供基于计算机的共同阅读
- 批准号:
2321439 - 财政年份:2024
- 资助金额:
$ 49.42万 - 项目类别:
Cooperative Agreement
SBIR Phase II: Development of a Novel Measurement Technology to Enable Longitudinal Multiomic Investigations of the Gut Microbiome
SBIR 第二阶段:开发新型测量技术以实现肠道微生物组的纵向多组学研究
- 批准号:
2314685 - 财政年份:2024
- 资助金额:
$ 49.42万 - 项目类别:
Cooperative Agreement