权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Investigating the Contribution of Membrane Trafficking to Cell Division

研究膜运输对细胞分裂的贡献

基本信息

批准号：
1158003
负责人：
Ahna Skop
金额：
$ 77.49万
依托单位：
University of Wisconsin-Madison
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-01 至 2018-05-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1158003&HistoricalAwards=false
关键词：
Investigating Contribution Membrane Trafficking Cell

项目摘要

INTELLECTUAL MERITDuring embryonic development, the identity of cells in tissues and organs is determined by a series of asymmetric divisions. Cell asymmetry is controlled by two mechanisms: cell polarity and cytokinesis. Errors in these events often lead to changes in cell proliferation and growth. The plasma membrane and underlying cell cortex play an important role in cell polarity and cytokinesis, yet very little is known about how it is regulated and maintained during development. To address this issue, the project is focused on the protein dynamin, which has an essential role in both of these events. It is hypothesized that dynamin influences cell polarity and facilitates the temporal and spatial control of the cytokinesis machinery through its role in endocytosis and actin dynamics. This project will employ an interdisciplinary strategy to reveal the role of the dynamin using a combination of genetics, cell and molecular biology and high-resolution, in vivo microscopy techniques. The project will focus on the early divisions of the nematode, Caenorhabditis elegans.BROADER IMPACTSThe work outlined in this proposal will be used in numerous minority outreach opportunities and scientific art shows. The P.I., Dr. Ahna Skop has extensive experience with outreach to minority groups at the local, state and national levels. Through her consistent involvement in the SACNAS, AISES and MARC programs at New Mexico State University, she has contributed to a very positive trend in minority graduate student enrollment on the UW-Madison campus. The P.I.'s dedication to increasing and retaining minority, undergraduate and graduate students in the STEM fields is a priority, and part of her mission is to make science accessible to every race and group and welcome these students any chance she gets. In addition, the P.I. has continued to pursue the curation of various scientific art shows nationally and internationally, which inherently promote the beauty of science and provide public access to scientific research.

智力优势在胚胎发育过程中，组织和器官中细胞的身份是由一系列不对称分裂决定的。细胞的不对称性由两种机制控制：细胞极性和胞质分裂。这些事件中的错误通常导致细胞增殖和生长的变化。质膜和下层细胞皮层在细胞极性和胞质分裂中起着重要作用，但很少有人知道它是如何在发育过程中调节和维持的。为了解决这个问题，该项目的重点是蛋白质动力蛋白，它在这两个事件中起着至关重要的作用。据推测，发动蛋白影响细胞极性，并通过其在胞吞和肌动蛋白动力学中的作用促进胞质分裂机制的时空控制。该项目将采用跨学科的策略，揭示动力蛋白的作用，使用遗传学，细胞和分子生物学和高分辨率，在体内显微镜技术的组合。该项目将侧重于线虫的早期分支，秀丽隐杆线虫。更广泛的影响本提案中概述的工作将用于许多少数民族外联机会和科学艺术展。私家侦探，Ahna Skop博士在地方、州和国家一级与少数群体的外联方面拥有丰富的经验。通过她在新墨西哥州州立大学的SACNAS，AISES和MARC计划的一贯参与，她促成了在威斯康星大学麦迪逊分校校园少数民族研究生入学的一个非常积极的趋势。私家侦探她致力于增加和留住STEM领域的少数民族、本科生和研究生是一个优先事项，她的部分使命是让每一个种族和群体都能接触到科学，并欢迎这些学生的任何机会。此外，PI。继续在国内和国际上策划各种科学艺术展，这些艺术展本质上促进了科学之美，并为公众提供了科学研究的机会。