IRFP: Determination of Solvent Effects and Interactions of Silica-Polypeptide Colloidal Particles by Small-Angle Neutron Scattering
IRFP:通过小角中子散射测定二氧化硅-多肽胶体颗粒的溶剂效应和相互作用
基本信息
- 批准号:1159189
- 负责人:
- 金额:$ 16.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Fellowship Award
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-01-01 至 2015-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The International Research Fellowship Program enables U.S. scientists and engineers to conduct nine to twenty-four months of research abroad. The program's awards provide opportunities for joint research, and the use of unique or complementary facilities, expertise and experimental conditions abroad. This award will support a twenty-four-month research fellowship by Dr. Javoris V. Hollingsworth to work with Prof. Charles Han at the Institute of Chemistry, Chinese Academy of Science in Beijing, China. The aim of this research project is to investigate the solvent effects, structural variations and the resulting shell interpenetration of silica-polypeptide colloidal particles. These particles are composed of a silica core, which may or may not possess a superparamagnetic inclusion (Co or Fe3O4). The shell consists of polypeptides covalently bonded to the core. Depending on the properties of the attached polymers, the particles can exhibit solubility in water or organic solvents. Also, the polypeptide coil-helix transition is a useful feature for modifying the surface configuration and particle interactions. These particles are candidates for several potential applications such as responsive materials, chiral separations, catalysis, colloidal crystallization, biomimetic membrane supports and drug delivery systems. A number of features about the particles have been described-for example, they can form colloidal crystals'but very little is known about the dynamic response of the particles under applied fields. An overall goal is to understand these properties and concurrently the findings will have a positive impact on the approach used to design novel responsive materials and devices. Small angle neutron scattering (SANS) studies are performed at the Neutron Scattering Laboratory, China Institute of Atomic Energy. This SANS device is one of the most recently built neutron systems in the world. After gaining experience with similar particles of interest developed by the host group, the general objective is to investigate shell structural properties as the particles are brought together under applied magnetic fields using SANS, coupled with dynamic light scattering (DLS). The combination of SANS and DLS is ideal for this study because both techniques permit real-time monitoring of structure variations. Particle interactions are detectable by SANS using deuterated and hydrogenous polypeptides covalently attached to silica cores. In addition to the usual development of international partnerships, publications and presentations, the PI will adapt his acquired skills to U.S. neutron sources. This continued research endeavor will contribute to the advancement of materials science by providing insight on microstructural and responsive properties of versatile core-shell colloidal systems.
国际研究奖学金计划使美国科学家和工程师能够在国外进行9至24个月的研究。该计划的奖项提供了联合研究的机会,以及使用国外独特或互补的设施,专业知识和实验条件。该奖项将支持Javoris V. Hollingsworth博士与Charles Han教授在中国北京中国科学院化学研究所进行为期24个月的研究。本研究的目的是探讨溶剂的影响,结构的变化和由此产生的二氧化硅-多肽胶体颗粒的壳互穿。这些颗粒由二氧化硅核组成,其可以具有或可以不具有超顺磁性夹杂物(Co或Fe 3 O 4)。外壳由与核心共价结合的多肽组成。取决于所连接的聚合物的性质,颗粒可以表现出在水或有机溶剂中的溶解性。此外,多肽卷曲-螺旋转变是用于修饰表面构型和颗粒相互作用的有用特征。这些粒子是几个潜在的应用,如响应材料,手性分离,催化,胶体结晶,仿生膜支持和药物输送系统的候选人。关于粒子的一些特性已经被描述过,例如,它们可以形成胶体晶体,但是对于粒子在外加场下的动态响应知之甚少。总体目标是了解这些特性,同时研究结果将对用于设计新型响应材料和器件的方法产生积极影响。小角中子散射(SANS)研究在中国原子能科学研究院中子散射实验室进行。这个SANS装置是世界上最新建造的中子系统之一。在获得由主机组开发的感兴趣的类似颗粒的经验后,总体目标是研究壳结构特性,因为颗粒在施加的磁场下使用SANS结合动态光散射(DLS)聚集在一起。SANS和DLS的组合是这项研究的理想选择,因为这两种技术都可以实时监测结构变化。粒子相互作用是可检测的SANS使用氘代和含氢多肽共价连接到二氧化硅核心。除了通常的国际合作伙伴关系,出版物和演示文稿的发展,PI将适应他所获得的技能,以美国中子源。这种持续的研究奋进将有助于材料科学的进步,提供洞察多功能核壳胶体系统的微观结构和响应特性。
项目成果
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