权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Separation of mixtures of chiral volatile anestethics via modified porous glasses

通过改性多孔玻璃分离手性挥发性麻醉剂混合物

基本信息

批准号：
206088065
负责人：
Professor Dr.-Ing. Andreas Seidel-Morgenstern
金额：
--
依托单位：
Max-Planck-Institut für Dynamik komplexer technischer Systeme
依托单位国家：
德国
项目类别：
Priority Programmes
财政年份：
2011
资助国家：
德国
起止时间：
2010-12-31 至 2015-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/206088065?language=en
关键词：
Separation mixtures chiral volatile anestethics

项目摘要

The separation of racemic mixture of fluranes applied as anaesthetic gases is of large interest, since the specific effects of the individual enantiomers is not sufficiently known. Corresponding investigations are still hampered due to the limited availability of the corresponding pure enantiomers.In the first period of this project glass beads of various pore and particle sizes were synthesized. It was possible to immobilize suitable cyclodextrin-based selectors on the surface of these beads and to perform first successful enantioseparations.In the currently ongoing funding period the synthesis of the supports has been improved further. Glass beads in which the pore structure was altered by pseudomorphic transformation were synthesized exhibiting already functionalized surfaces. The synthesis was reproducible and larger amounts of samples could be provided for chromatographic investigations. In comparison to the pathway used in the first period, the fixation of the enantioselective selector could be further improved allowing for better separation results. A more detailed characterization regarding the intraparticle mass transport of chiral molecules was performed exploiting IR micro-imaging. Adsorption capacities and separation factors were determined analyzing results of chromatographic column overloading experiments. A simplified mathematical model, which is capable to describe and optimize the chromatographic columns filled with the prepared particles, was developed and applied to estimate the productivity of the separation for columns with larger diameters.The production of pure enantiomers is in the focus of the third funding period. Larger column dimensions and an improved experimental set-up should be used. The enantiomers leaving the separation column should be subsequently captured in an adsorber before desorbing and condensing them. It is further planned to test the applicability of the model developed with respect to predict the separation process occurring in larger columns over a wider parameter range. An anticipated extension of the model will be realized by incorporating available transport parameters. In addition, it is planned in the third period to perform orienting small scale experiments with new particles of larger diameter and with core-shell-particles. These new supports are potentially advantageous for later separations in an even larger scale.

作为麻醉气体的氟烷的外消旋混合物的分离受到极大的关注，因为单个对映体的具体作用还不充分了解。由于相应的纯对映体的可用性有限，相应的研究仍然受到阻碍。在本项目的第一阶段，合成了各种孔径和粒径的玻璃珠。在这些微珠的表面上嵌入合适的基于环糊精的选择剂并进行首次成功的对映体分离是可能的。在目前正在进行的资助期间，载体的合成得到了进一步改进。合成了其中孔结构通过假晶转化而改变的玻璃珠，其表现出已经官能化的表面。该合成方法重现性好，可为色谱研究提供大量样品。与第一阶段中使用的途径相比，可以进一步改进对映选择性选择剂的固定，从而获得更好的分离结果。一个更详细的表征关于手性分子的粒子内质量传输进行利用红外显微成像。通过对色谱柱超载实验结果的分析，确定了吸附容量和分离因子。开发了一个简化的数学模型，该模型能够描述和优化填充有所制备颗粒的色谱柱，并用于估计较大直径色谱柱的分离生产率。应使用更大的色谱柱尺寸和改进的实验装置。离开分离柱的对映异构体应随后在解吸和冷凝它们之前在吸附器中捕获。进一步计划测试开发的模型在预测较大色谱柱在更宽参数范围内发生的分离过程方面的适用性。通过纳入现有的运输参数，该模型的预期扩展将得以实现。此外，计划在第三阶段用直径较大的新粒子和核-壳粒子进行定向小规模实验。这些新的载体对于以后更大规模的分离是潜在有利的。