RUI: Carbaporphyrins, Neo-Confused Porphyrins and Related Systems

RUI：碳卟啉、新混乱卟啉及相关系统

• 批准号: 1212691
• 负责人: Timothy Lash
• 金额: $ 30万
• 依托单位: Board of Trustees of Illinois State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1212691&HistoricalAwards=false
• 关键词: RUI; Carbaporphyrins; Neo; Confused; Porphyrins

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Timothy D. Lash of the Department of Chemistry at Illinois State University will explore the synthesis, characterization, and reactivity of porphyrin-like macrocycles, including neo-confused porphyrins and other carbaporphyrinoid systems. Specifically, syntheses of heterobenziporphyrins and heteropyriporphyrins will be developed using a "3 + 1" strategy. The chemistry of previously prepared monocarbaporphyrins will also be studied. A strategy for synthesizing carbaporphyrins and carbachlorins from a cyclopentene dialdehyde and a new route to benzocarbaporphyrins from 6-methoxyazulene will be developed. General approaches to the synthesis of a new class of porphyrin isomers known as neo-confused porphyrins will be investigated. In addition to dicarbaporphyrinoids, tri- or tetracarbaporphyrinoid systems will be studied.This work will not only lead to more efficient routes to carbaporphyrinoid systems but will also allow access to new classes of porphyrin analogues. This project is important to improve our basic understanding of fundamental chemistry concepts such as aromaticity. It also has practical applications for the synthesis of fine chemicals, since the target compounds can be used to construct catalysts for chemical synthesis. In addition, the target compounds are important in medicines, as they have potential applications in photodynamic therapy. These projects not only provide an excellent environment for training undergraduates and master level graduate students in the field of organic synthesis, but they also expose them to the multidisciplinary nature of modern scientific research.

在这个由化学系化学合成计划资助的项目中，伊利诺伊州立大学化学系的Timothy D.Lash教授将探索类似卟啉的大环的合成、表征和反应活性，包括新混淆的卟啉和其他碳卟啉系统。具体地说，将利用“3+1”策略开发杂苯并卟啉和杂吡咯的合成。还将研究先前制备的单碳卟啉的化学。将开发一种由环戊烯二醛合成碳卟啉和卡氯啉的策略，以及一条由6-甲氧基天青烯合成苯并碳卟啉的新路线。将研究合成一类新的被称为新混杂的卟啉的卟啉异构体的一般方法。除了二碳卟啉以外，还将研究三或四碳卟啉系统。这项工作不仅将导致更有效的碳卟啉系统的路线，而且还将允许获得新类别的卟啉类似物。这个项目对提高我们对芳香性等基本化学概念的基本理解很重要。由于目标化合物可以用来构建化学合成的催化剂，因此它在合成精细化学品方面也有实际应用。此外，目标化合物在药物中很重要，因为它们在光动力疗法中有潜在的应用。这些项目不仅为培养有机合成领域的本科生和硕士研究生提供了良好的环境，而且还使他们接触到现代科学研究的多学科性质。