New Chemical Diversity from Coastal Myxobacteria

沿海粘细菌的新化学多样性

• 批准号: 1214065
• 负责人: Phillip Crews
• 金额: $ 30万
• 依托单位: University of California-Santa Cruz
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1214065&HistoricalAwards=false
• 关键词: New; Chemical; Diversity; Coastal; Myxobacteria

With this award, the Chemistry of Life Processes Program is supporting Professor Phillip Crews in the Department of Chemistry & Biochemistry at the University of California at Santa Cruz. The focus is on myxobacteria, which represent a unique system for the study of bio-complexity. They spread over a surface by swarming and often out-compete other organisms for nutrients. Fundamental knowledge about their basic physiology including colonization processes, prokaryotic development, genetics, and chemotaxis is emerging but at a rather slow pace. This study aims to increase fundamental knowledge on the myxobacteria taxa obtained from the ocean/land interface, and seeks to uncover new biological systems possessing functional pathways for secondary metabolites. The project invokes a combination of environmental sampling, bioorganic functional chemistry analysis, and microbial taxonomy. Identifying and characterizing unique myxobacterial strains obtained from untapped ecological niches with the capacity to biosynthesize novel chemical scaffolds is the core activity. The Broader Impact of this project involves developing unique research tools and technology to allow discovery and characterization of molecular structures that will be new to science. It is anticipated that unprecedented structural chemical results will be obtained. Thus, the project design will provide opportunities for the Crews team to discover, share, and inspire others. The prospects for training are also important and will accelerate the scientific growth of all project participants anticipated to include young scientific professionals, postdoctoral fellows, PhD candidates, and undergraduate students. Also of note is that the PI is one of the few at UCSC from an underrepresented group. He continues to work diligently to insure that UCSC persists in a strong tradition of leadership to promote the advancement of minorities and women in the fields of bioorganic chemistry and chemical biology.

有了这个奖项，生命过程计划的化学是支持教授菲利普船员在化学生物化学系在加州大学圣克鲁斯。重点是粘细菌，这是一个独特的系统，为生物复杂性的研究。它们通过群集在表面上传播，并且经常与其他生物竞争营养。关于其基本生理学的基础知识，包括殖民过程，原核发育，遗传学和趋化性正在出现，但速度相当缓慢。 本研究的目的是增加从海洋/陆地界面获得的粘细菌类群的基础知识，并寻求发现新的生物系统具有功能途径的次级代谢产物。该项目结合了环境采样、生物有机功能化学分析和微生物分类学。 鉴定和表征从未开发的生态位获得的具有生物合成新型化学支架能力的独特粘细菌菌株是核心活动。该项目的更广泛的影响涉及开发独特的研究工具和技术，以允许发现和表征分子结构，这将是新的科学。预计将获得前所未有的结构化学结果。 因此，项目设计将为船员团队提供发现，分享和激励他人的机会。培训的前景也很重要，将加速所有项目参与者的科学成长，预计包括年轻的科学专业人员，博士后研究员，博士候选人和本科生。同样值得注意的是，PI是UCSC少数几个来自代表性不足的群体之一。他继续努力工作，以确保UCSC坚持领导的强大传统，以促进少数民族和妇女在生物有机化学和化学生物学领域的进步。