Unleashing the Hidden Chemical Diversity in Australian Fungi

释放澳大利亚真菌中隐藏的化学多样性

• 批准号: LP210100458
• 负责人: A/Prof Yit-Heng Chooi
• 金额: $ 55.73万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-05-11 至 2025-05-10
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP210100458
• 关键词: Unleashing; Hidden; Chemical; Diversity; Australian

This project aims to exploit an exclusive genomic resource consisting of >150 unique Australian filamentous fungi that has been built in a university-industry collaboration for genomic-guided biodiscovery. The genome sequence of these fungi revealed extensive hidden genetic instructions for production of novel biologically active molecules. The project will apply cutting-edge synthetic biology and chemical tools to tap into the hidden genomic potential of these Australian fungi. Expected outcomes of this project include new fine chemicals and lead molecules with desirable bioactivies. This will provide significant benefits to Australia's economy through the discovery of new pharmaceuticals, veterinary products and agrichemicals.

该项目旨在利用由超过150种独特的澳大利亚丝状真菌组成的独家基因组资源，这些真菌是在大学与工业合作中建立的，用于基因组指导的生物发现。这些真菌的基因组序列揭示了广泛的隐藏的遗传指令，用于生产新的生物活性分子。该项目将应用尖端的合成生物学和化学工具来挖掘这些澳大利亚真菌隐藏的基因组潜力。该项目的预期成果包括新的精细化学品和具有理想生物活性的铅分子。这将通过发现新的药品、兽医产品和农用化学品，为澳大利亚经济带来重大利益。