SBIR Phase I: Efficient and Scalable Production of Functionalized Electrospun Nanofiber Felts of Regenerated Cellulose with Superior Capacity and Throughput for Bioseparations

SBIR 第一阶段：高效、可规模化生产再生纤维素功能化电纺纳米纤维毡，具有卓越的生物分离能力和吞吐量

• 批准号: 1214877
• 负责人: Nyle Hedin
• 金额: $ 15万
• 依托单位: Nanofiber Separations, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1214877&HistoricalAwards=false
• 关键词: SBIR; Phase; Efficient; Scalable; Production

This Small Business Innovation Research (SBIR) Phase I project from Nanofiber Separations, LLC will establish an innovative type of bioseparation media utilizing electrospun nanofiber felts of regenerated cellulose with high specific surface area as the support for protein adsorption ligands. Compared to competitive products (e.g., packed resin beads or microfiber adsorption membranes), these nanofiber membranes/felts will provide greatly enhanced throughput (i.e., shorter processing times), reduce the amount of waste generated, and decrease the volume of media required (i.e., lower costs and smaller operating footprints) for purification of high-value biopharmaceutical products. The study of these separation materials and processes will increase the scientific knowledge of the absorption characteristics of biomaterials at the nanoscale. This SBIR Phase I project will focus on optimization of a scalable production process for the felts, including pilot scale production of the nanofiber mats, along with functionalization of the fibers for superior capacity, elevated throughput, and highly selective bioseparations. The broader impact/commercial potential of this project centers on providing advanced separation media for the biopharmaceutical, water purification, and blood products industries. Because of the advantages of the proposed product, the innovative adsorption felts produced from electrospun nanofibers of regenerated cellulose have a tremendous amount of commercial potential. Customers will come from companies within the biopharmaceutical industry, as well as the established manufacturers of bioseparations adsorption media. In addition, the underlying fundamentals associated with nanofiber adsorption media will have a wide range of implications, including the water purification industry and the blood products and/or blood purification industries. The advantages achieved through this innovative work will lead to more efficient separation technologies across many sectors, such as faster processes, reduced energy consumption, lower materials requirements, and less waste generation. In addition to the broader scientific impacts, Nanofiber Separations, LLC is committed to creating jobs and and training highly technical staff members with expertise in the interdisciplinary fields of nanoscience/nanoengineering and biotechnology.

来自Nanofiber Separations，LLC的这一小型企业创新研究（SBIR）第一阶段项目将建立一种创新类型的生物分离介质，利用具有高比表面积的再生纤维素的静电纺丝毡作为蛋白质吸附配体的支持。 与竞争产品相比（例如，填充的树脂珠或微纤维吸附膜），这些微孔膜/毡将提供大大提高的生产量（即，更短的处理时间），减少产生的废物量，并减少所需的介质体积（即，更低的成本和更小的操作占地面积）用于高价值生物制药产品的纯化。这些分离材料和过程的研究将增加对纳米生物材料吸收特性的科学认识。 该SBIR第一阶段项目将专注于优化毛毡的可扩展生产工艺，包括中试规模生产的纤维毡，沿着纤维的功能化，以实现上级能力，提高产量和高度选择性的生物分离。 该项目更广泛的影响/商业潜力集中在为生物制药、水净化和血液制品行业提供先进的分离介质。 由于所提出的产品的优点，由再生纤维素的电纺纳米纤维生产的创新吸附毡具有巨大的商业潜力。 客户将来自生物制药行业的公司，以及生物分离吸附介质的成熟制造商。 此外，与吸附介质相关的基本原理将具有广泛的含义，包括水净化工业和血液制品和/或血液净化工业。 通过这项创新工作实现的优势将导致许多部门的更有效的分离技术，例如更快的流程，降低能耗，降低材料要求和减少废物产生。 除了更广泛的科学影响，Nanofiber Separations，LLC致力于创造就业机会和培训具有纳米科学/纳米工程和生物技术跨学科领域专业知识的高技术人员。