SBIR Phase II: Efficient and Scalable Production of Functionalized Electrospun Nanofiber Felts of Regenerated Cellulose with Superior Capacity and Throughput for Bioseparations

SBIR 第二阶段：高效、可规模化生产再生纤维素功能化电纺纳米纤维毡，具有卓越的生物分离能力和吞吐量

• 批准号: 1329377
• 负责人: Nyle Hedin
• 金额: $ 75万
• 依托单位: Nanofiber Separations, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1329377&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Efficient; Scalable

This Small Business Innovation Research (SBIR) Phase II project from Nanofiber Separations, LLC will establish an innovative type of bioseparation media utilizing electrospun nanofiber felts/mats of regenerated cellulose with high specific surface area as the support for protein adsorption ligands. Compared to competitive products (e.g., packed resin beads or microfiber adsorption membranes), these nanofiber membranes/felts will provide greatly enhanced throughput (i.e., shorter processing times), reduce the amount of waste generated, and decrease the volume of media required (i.e., lower costs and smaller operating footprints) for purification of high-value biopharmaceutical products. The SBIR Phase I project was completed successfully by developing a manufacturing process for the functionalized nanofiber felts and proving superior performance compared to commercial products. This SBIR Phase II project will focus on further optimization of the formulations used during production of the nanofiber adsorbents for bioseparations. This will include two scale-up steps needed for the commercial manufacturing effort anticipated during the Phase II timeline (nanofiber felt production, surface functionalization, and module development). Key technical improvements, including greater product stability and a broader array of functional ligands needed in bioseparations, will continue to be made to the nanofiber felts/mats. The broader impact/commercial potential of this project goes well beyond bioseparations. Due to the many advantages of the surface-functionalized electrospun nanofibers made from regenerated cellulose, this innovative adsorption material has tremendous commercial potential. Customers will come from companies within the biopharmaceutical industry, as well as from the established manufacturers of bioseparations adsorption media. Additionally, the underlying fundamentals associated with nanofiber adsorption media will have a wide range of implications, including more efficient separation processes in the water purification industry and the blood products and/or blood purification industries. The advantages achieved through this innovative work will lead to more efficient separation technologies across many sectors and include faster processes, reduced energy consumption, lower materials requirements, and less waste generation. In addition to the broader scientific impacts, Nanofiber Separations, LLC is committed to creating jobs and to training highly technical staff members, providing them with expertise in the interdisciplinary fields of advanced functional materials (including nano-scaled materials) and/or biotechnology.

Nanofiber Separations，LLC的这一小型企业创新研究（SBIR）第二阶段项目将建立一种创新类型的生物分离介质，该介质利用具有高比表面积的再生纤维素的静电纺丝毡/垫作为蛋白质吸附配体的支持物。与竞争产品相比（例如，填充的树脂珠或微纤维吸附膜），这些微孔膜/毡将提供大大提高的生产量（即，更短的处理时间），减少产生的废物量，并减少所需的介质体积（即，更低的成本和更小的操作占地面积）用于高价值生物制药产品的纯化。SBIR第一阶段项目成功完成，开发了功能化毛毯的制造工艺，并证明了与商业产品相比具有上级性能。SBIR第二阶段项目将重点关注生物分离吸附剂生产过程中使用的配方的进一步优化。这将包括在第II阶段时间轴期间预期的商业生产工作所需的两个规模扩大步骤（毛毡生产、表面功能化和模块开发）。关键的技术改进，包括更大的产品稳定性和生物分离所需的更广泛的功能配体，将继续对生物毡/垫进行。该项目更广泛的影响/商业潜力远远超出了生物分离。由于再生纤维素制备的表面功能化电纺纳米纤维的许多优点，这种创新的吸附材料具有巨大的商业潜力。客户将来自生物制药行业的公司，以及来自生物分离吸附介质的成熟制造商。此外，与吸附介质相关的基本原理将具有广泛的含义，包括水净化工业和血液制品和/或血液净化工业中更有效的分离过程。通过这项创新工作实现的优势将导致许多部门的更有效的分离技术，包括更快的流程，降低能耗，降低材料要求和减少废物产生。除了更广泛的科学影响，Nanofiber Separations，LLC致力于创造就业机会和培训高技术人员，为他们提供先进功能材料（包括纳米材料）和/或生物技术的跨学科领域的专业知识。