SBIR Phase I: A Wafer-Scale Flat-Panel X-ray Source with Raster Control

SBIR 第一阶段：具有光栅控制的晶圆级平板 X 射线源

• 批准号: 1215594
• 负责人: Kristin Schmiedehausen
• 金额: $ 14.83万
• 依托单位: Radius Diagnostics Research
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1215594&HistoricalAwards=false
• 关键词: SBIR; Phase; Wafer; Scale; Flat

This Small Business Innovation Research (SBIR) Phase I project seeks to demonstrate key enabling technologies for a novel medical imaging x-­‐ray source. For over a century, medical imaging has relied on fundamentally the same approach to generate x-­‐rays: production in vacuum tubes, which are fragile, heavy, not portable, and expensive. This proposal presents a method that allows the x-­‐ray source to move from tubes to a robust flat-­‐panel system produced in much the same way as modern televisions; matching state-­‐of-­‐the-­‐art flat-­‐panel Digital Radiology (DR) detector and dramatically changing the economics and application profile of x-­‐ray devices. The anticipated outcome of Phase I is a proof-­‐of-­‐concept showing sufficient high-­‐quality x-­‐ray flux can be generated from the proposed portable flat-­‐panel source and that the array of emitters can be addressed (rastered). Simulations will also show that these devices will perform as expected and conform to the clinical needs and technical standards in radiology. Microfabrication will be used to produce a prototype system. The broader impact/commercial potential of this project is a dramatic shift in how medical imaging is delivered to the patient. The x-­‐ray source being developed under this proposal would be highly portable and robust. Such a device could be carried by first responders, but it would also improve portable x-­‐ ray radiology within the hospital. Current equipment for use in the Intensive Care Unit (ICU) and Emergency Room (ER), where radiology must travel to the patient is bulky, cumbersome and uncomfortable in use. The device proposed would reduce the cost and discomfort associated with such equipment, as well as fundamentally changing the economics of the fixed radiology in hospitals. The proposed technology has the potential to reduce patient radiation exposure while maintaining image quality, and improve advanced imaging including dual energy x-­‐ray scans, mammography, tomosynthesis and fluoroscopy through Region of Interest selection: it can help save lives, provide healthcare to a wider population at lower costs, and in locations not previously accessible.

这个小型企业创新研究(SBIR)第一阶段项目旨在展示一种新型医学成像X射线源的关键使能技术。一个多世纪以来，医学成像基本上一直依赖于同样的方法来产生X射线：在真空管中产生射线，这种真空管脆弱、笨重、不便于携带，而且价格昂贵。这项提议提出了一种方法，允许X射线源从管子移动到坚固的平板系统，其生产方式与现代电视几乎相同；匹配state-­&amp；#8208；of-­&amp；#8208；the-­&amp；#8208；art平板数字放射(DR)探测器，并极大地改变X射线设备的经济性和应用概况。第一阶段的预期结果是一个概念的证明，表明可以从建议的便携式平板光源产生足够高质量的射线通量，并且发射器阵列可以被寻址(栅格)。模拟还将表明，这些设备的性能将达到预期，并符合临床需求和放射学的技术标准。微制造将被用于生产原型系统。这个项目的更广泛的影响/商业潜力是向患者提供医学成像的方式发生了戏剧性的转变。根据这一提议正在开发的X射线源将是高度便携和坚固的。这样的设备可以由急救人员携带，但它也将改善医院内的便携式X射线放射学。目前在重症监护病房(ICU)和急诊室(ER)使用的设备笨重、笨重，而且使用起来不舒服。拟议的设备将降低与此类设备相关的成本和不适感，并从根本上改变医院固定放射科的经济性。这项拟议的技术有可能在保持图像质量的同时减少患者的辐射暴露，并通过感兴趣的区域选择改进先进的成像技术，包括双能量X射线扫描、乳房X光摄影、断层合成和荧光透视：它可以帮助挽救生命，以更低的成本向更广泛的人群提供医疗保健，而且是在以前无法进入的地点。