Sensory-affective Interaction and Body Perception in BPD

BPD 中的感觉情感相互作用和身体知觉

• 批准号: 206469445
• 负责人: Dr. Robin Bekrater-Bodmann
• 金额: --
• 依托单位: Klinik für Psychiatrie, Psychotherapie und Psychosomatik
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/206469445?language=en
• 关键词: Sensory; affective; Interaction; Body; Perception

BPD is characterized by dissociative symptoms that include intermittent somatosensory integration deficits and alterations in body perception. Frontoparietal dysfunctions, especially involving the temporo parietal junction (TPJ), may represent key mechanisms related to the processing of and interaction between the self and the environment. Our proposed project aims at the elucidation of psychobiological mechanisms of dissociative states and the evaluation of their importance for the psychopathology of BPD. In study 1, after the induction of dissociation or a neutral control condition, we will perform experiments that use of the processing of pain and pleasant touch as a tool to understand the perceptual mechanisms related to dissociative states. In study 2, we will facilitate or inhibit the activity of the TPJ or a control site using a neuronavigated transcranial magnetic stimulation (TMS) protocol. We will examine its effects on sensory integration associated with body perception and the processing of somatosensory stimuli with positive or negative valence, and their association with dissociation. By revealing the psychobiological basis and consequences of dissociative states, the results might enhance our understanding of the complex perceptual alterations in BPD.

BPD的特征是分离症状，包括间歇性躯体感觉整合缺陷和身体感知的改变。额顶叶功能障碍，特别是涉及颞顶叶交界处（TPJ），可能代表与自我和环境之间的处理和相互作用有关的关键机制。我们建议的项目旨在阐明分离状态的心理生物学机制，并评估其对BPD精神病理学的重要性。在研究1中，在诱导分离或中性控制条件后，我们将进行实验，使用疼痛和愉快的触摸作为工具来理解与分离状态相关的知觉机制。在研究2中，我们将使用神经导航经颅磁刺激（TMS）方案促进或抑制TPJ或对照部位的活动。我们将研究其对感觉统合与身体知觉和躯体感觉刺激的处理与积极或消极的效价，以及他们与解离的关系。通过揭示分离状态的心理生物学基础和后果，这些结果可能会增强我们对BPD复杂感知变化的理解。