Pain and pleasure: affective somatosensory processing and emotion regulation in borderline personality disorder

痛苦与快乐：边缘性人格障碍的情感体感处理和情绪调节

• 批准号: 532907629
• 负责人: Dr. Robin Bekrater-Bodmann
• 金额: --
• 依托单位: Klinik für Psychiatrie, Psychotherapie und Psychosomatik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/532907629?language=en
• 关键词: Pain; pleasure; affective; somatosensory; processing

Previous evidence points to a significant role of pain in the context of disturbed emotion regulation in borderline personality disorder (BPD). However, since there is evidence for a common neurobiology underlying both pain and pleasure, there is reason to assume that BPD-associated alterations in the processing of sensory-affective input are not restricted to negatively evaluated somatosensory stimulation, but also affect the processing of somatosensory input which usually is positively evaluated. Our own preliminary results suggest that individuals with BPD not only report reduced sensitivity to pain, but also to pleasant touch (PT), that is, a somatosensory percept with positive valence mediated by C-tactile fibres, which in non-clinical individuals is important for non-verbal social communication and associated with stress relief. However, the actual nature of disturbed PT processing, its neural underpinnings, and its interaction with disturbed social processes in BPD are still unknown. Focusing on BPD, this project therefore has three aims: (1) the characterization of disturbed affective somatosensory processing and its relationship to BPD psychopathology and aetiological factors, (2) the elucidation of neural network activity associated with pleasant and unpleasant somatosensory stimulation, and (3) the evaluation of the effects of affective touch on social stress. Dimensionally assessed personality pathology, non-suicidal self-injurious behaviour, as well as a history of traumatization will be related to perceptual and behavioural characteristics. We expect that the findings will reveal unknown mechanisms underlying affective somatosensory processing and its relationship to emotion regulation in BPD.

以前的证据表明，疼痛在交界性人格障碍(BPD)的情绪调节紊乱的背景下起着重要作用。然而，由于有证据表明疼痛和快乐都有共同的神经生物学基础，所以有理由假设BPD在感觉-情感输入的处理过程中的相关变化不仅限于负面评估的体感刺激，而且还影响通常被积极评估的体感输入的处理。我们自己的初步结果表明，BPD患者不仅对疼痛的敏感度降低，而且对愉悦触摸(PT)的敏感度也降低，即由C-触觉纤维介导的具有正价的体感知觉，在非临床个体中，这对于非言语社交和压力缓解是重要的。然而，被扰乱的PT加工的实际性质、其神经基础以及它与BPD中被扰乱的社会过程的相互作用仍不清楚。因此，本项目以BPD为研究对象，有三个目标：(1)BPD情感躯体感觉加工障碍的特征及其与BPD精神病理学和病因学因素的关系；(2)阐明与愉快和不愉快的躯体感觉刺激相关的神经网络活动；(3)评估情感触摸对社会应激的影响。经维度评估的人格病理、非自杀性自残行为以及精神创伤病史将与知觉和行为特征有关。我们期望这些发现将揭示BPD情感躯体感觉加工的未知机制及其与情绪调节的关系。