Neural Mechanisms of Trust and Dyadic Interaction in BPD

BPD 中信任和二元相互作用的神经机制

• 批准号: 206468010
• 负责人: Professor Dr. Peter Kirsch
• 金额: --
• 依托单位: Klinik für Psychiatrie und Psychotherapie
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/206468010?language=en
• 关键词: Neural; Mechanisms; Trust; Dyadic; Interaction

Aim of IP3 is the identification of abnormal interbrain activity and connectivity during impaired interpersonal processes in BPD using hyperscanning which permits the measurement of brain activity simultaneously in two interacting people. During the first funding period, we established a new, generalizable, robust and hypothesis-free analysis method for hyperscanning data while collecting data from both healthy controls and patients. A Joint Attention (JA) task was chosen for the initial investigation, since it represents a fundamental, simple and developmentally early form of specifically human social interaction. Data from two healthy samples showed that during JA, coupling between brain systems emerges that is unique to truly interacting subjects, and temporally and spatially highly specific, centering on the right temporo-parietal junction (rTPJ). In our first study, currently involving 22 BPD pairs, formed from patient interacting with one control participant, we found that neural coupling parameters during JA were affected by illness status. No significant coupling in dyads involving a BPD subject was observable during JA, providing the first observation of a disruption in this early processing stage of social information in BPD. In addition, initial analysis of the 2nd study, a multi-round trust game showed a comparable reduction in rTPJ coupling when BPD patients were involved in the interaction. This result might indicate that we identified a fundamental neural mechanism of social interaction, interbrain coupling, which is already impaired in BPD patients in very basal kinds of social interaction but affects social functioning on all levels of complexity. Disturbed JA has been extensively investigated in autism spectrum disorders (ASD). Recently a subgroup BPD patients has been described that also meets the criteria for ASD. It would therefore be interesting to test whether the reduced coupling during JA can also be observed in ASD patients and whether we identified a shared mechanism affecting social functioning in BPS and ASD. Therefore, we now aim to further characterize and explore neural coupling during JA and its disturbance in BPD patients. We will first investigate associations between disturbed neural coupling during JA, clinical ASD features and social functions in BPD and ASD patients. Second, we will investigate the genetic underpinnings of impaired coupling during JA specifically emphasizing the role of the oxytocin receptor gene (OXTR). Third, we will investigate the change of the signature over the course of the disorder looking on a larger sample of remitted BPD patients and fourth, we will investigate JA within borderline dyads in more details. In addition, to directly relate rTPJ function to social interaction, we will conduct a pilot study in BPD and ASD patients, where we use transcranial magnetic stimulation (TMS) to excite the region and test resulting effects on neural coupling parameters during social interaction.

IP3的目的是利用超扫描来识别BPD中受损人际过程中的异常脑间活动和连通性，这种超扫描可以同时测量两个相互作用的人的大脑活动。在第一个资助期内，我们建立了一种新的、可推广的、稳健的、无假设的超扫描数据分析方法，同时从健康对照和患者中收集数据。最初的研究选择了联合注意（JA）任务，因为它代表了一种基本的、简单的、发育早期的人类社会互动形式。来自两个健康样本的数据表明，在JA过程中，大脑系统之间的耦合出现了，这是真正相互作用的受试者所特有的，并且在时间和空间上高度特异性，以右侧颞顶交界处（rTPJ）为中心。在我们的第一项研究中，目前涉及22对BPD对，由患者与一个对照参与者相互作用形成，我们发现JA期间的神经耦合参数受到疾病状态的影响。在JA过程中，没有观察到涉及BPD受试者的双成对的显著耦合，这是首次观察到BPD社会信息早期加工阶段的中断。此外，第二项研究的初步分析，一个多轮信任游戏显示，当BPD患者参与互动时，rTPJ耦合也有相当的减少。这一结果可能表明我们发现了一种社会互动的基本神经机制，即脑间耦合，这种机制在BPD患者中已经在非常基础的社会互动中受损，但在所有复杂程度上影响社会功能。干扰JA在自闭症谱系障碍（ASD）中得到了广泛的研究。最近，BPD患者的一个亚组也符合ASD的标准。因此，测试JA期间的耦合减少是否也可以在ASD患者中观察到，以及我们是否确定了影响BPS和ASD社会功能的共同机制，将是有趣的。因此，我们现在的目标是进一步表征和探讨BPD患者JA期间的神经耦合及其障碍。我们将首先研究JA时神经耦合紊乱、BPD和ASD患者的临床特征和社会功能之间的关系。其次，我们将研究JA过程中偶联受损的遗传基础，特别强调催产素受体基因（OXTR）的作用。第三，我们将在更大的BPD患者样本中研究该疾病过程中特征的变化，第四，我们将更详细地研究边缘型二人组中的JA。此外，为了直接将rTPJ功能与社会互动联系起来，我们将在BPD和ASD患者中进行一项试点研究，我们使用经颅磁刺激（TMS）来刺激该区域，并测试其对社会互动中神经耦合参数的影响。

项目成果

State-Dependent Cross-Brain Information Flow in Borderline Personality Disorder

• DOI: 10.1001/jamapsychiatry.2017.1682
• 发表时间: 2017-09-01
• 期刊: JAMA PSYCHIATRY
• 影响因子: 25.8
• 作者: Bilek, Edda;Stoessel, Gabriela;Meyer-Lindenberg, Andreas
• 通讯作者: Meyer-Lindenberg, Andreas

Information flow between interacting human brains: Identification, validation, and relationship to social expertise

• DOI: 10.1073/pnas.1421831112
• 发表时间: 2015-04-21
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Bilek, Edda;Ruf, Matthias;Meyer-Lindenberg, Andreas
• 通讯作者: Meyer-Lindenberg, Andreas