Network for Computational Nanotechnology - NanoBIO Node

计算纳米技术网络 - NanoBIO 节点

• 批准号: 1227034
• 负责人: Emad Tajkhorshid
• 金额: $ 350万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1227034&HistoricalAwards=false
• 关键词: Network; Computational; Nanotechnology; NanoBIO; Node

This proposal aims to establish the nanoBIO node of the reconfigured Network for Computational Nanotechnology (NCN) at Illinois. The proposed node will create extensive online resources with the purpose to position the NCN Cyber Platform as the focal point for collaborative interactions of a diverse computational and experimental nanoBIO community. Although the proposal covers a comprehensive range of activities, the overriding goal is to organize the node as the first step towards a nanoBIO eco-system, by completing a set of four high-priority technical objectives: 1) development of critical online computational tools as essential building blocks for nanoBIO device simulation and experimental validation; 2) development of workflows linking simulations at different scales and leading to an extensible online environment for nanoBIO device design; 3) creation of transformative educational resources for biology, infusing modern nanoscience concepts via interactive simulation and visualization; 4) demonstration of a new paradigm for information sharing and knowledge discovery, with innovative scalable databases for searchable collections of computational and experimental nanoBIO datasets.To optimize the available resources, the nanoBIO node planning strategy has been to organize a network within the network, reaching out to key bioengineering and life science groups on campus, followed by forging partnerships with related IGERT programs, multi-university centers, and industrial collaborations to create a national fabric of interactions. A key partnership has also been established with the University of California-Merced to capitalize on existing collaborations in research and education and to leverage their computational biology based undergraduate programs. A cooperative effort to design engaging material between UC-Merced and the School of Molecular and Cellular Biology at UIUC will drive the NCN to become a revolutionary biology classroom environment that integrates research with education and stimulates undergraduates to develop interdisciplinary thinking, mirroring the IGERT mission. These rich online resources will also facilitate the access and understanding of nanoBIO concepts in K-12 education. To address the focus on devices and systems, the nanoBIO node will engage laboratories at UIUC with cutting-edge expertise in computational biology, bio-device fabrication and information technology, these laboratories include: the Beckman Institute, the Micro & Nanotechnology Laboratory, the Institute for Genomic Biology, and the National Center for Supercomputing Applications. UC Merced will also play an important role in creating and directing qualified underrepresented students towards pursuing careers in nanoBIO disciplines.Intellectual Merit: An immense challenge faced by designers and manufacturers of nanoBIO devices and systems is the lack of integrated computational and training tools addressing the multiple length scales and the physical complexity needed to bridge biology with engineering. The establishment of a dedicated nanoBIO node of NCN provides an exciting opportunity to address this and formulates a comprehensive plan with nation-wide reach to support nanoBIO research and education. The vision for this NCN nanoBIO node is to form an active community that accelerates the creation of multidisciplinary computational tools and transformative training materials in nanoscience and nanoengineering for the design of novel nanoBIO devices and systems that will have a positive influence on our quality of life and environment. This effort will have a major impact on the development of human resources by facilitating training. The availability of online tools will also benefit industry, particularly small businesses and nanoBIO start-ups needing access to specialized resources.Broader Impact: The urgency to contain health care costs and improve services, the imperatives to provide safe and plentiful food supplies, and the need for efficient bio-fuel production as part of a sustainable energy strategy all point to biology as the pivotal science of the future, and nanotechnology as the enabler. The ultimate goal of the nanoBIO node is to create resources for the discovery of devices suitable for nanoBIO applications, and to train the next generation of leaders who will translate nanoBIO technologies from research to the marketplace. These are crucial steps toward sustained transformation and revitalization of the health care industry, with broad potential impact on the creation of new high-tech jobs in an important manufacturing sector in the US. A new breed of scientists and engineers, with expertise across multiple physical and life science disciplines, is needed to sustain this vision. The node aspires to be the catalysts for truly innovative interdisciplinary education opportunities, putting forward an exciting educational plan which lays the foundations for a multi-faceted and integrated K-to-PhD pathway.

该提案旨在建立伊利诺伊州重新配置的计算纳米技术网络（NCN）的nanoBIO节点。拟议的节点将创建广泛的在线资源，目的是将NCN网络平台定位为不同计算和实验nanoBIO社区协作互动的焦点。虽然该提案涵盖了一系列全面的活动，但最重要的目标是通过完成一组四个高优先级的技术目标来组织节点，作为迈向nanoBIO生态系统的第一步：1）开发关键的在线计算工具，作为nanoBIO设备模拟和实验验证的基本构件; 2）开发工作流程，将不同规模的模拟连接起来，并为nanoBIO设备设计提供可扩展的在线环境; 3）创建生物学的变革性教育资源，通过交互式模拟和可视化注入现代纳米科学概念; 4）展示信息共享和知识发现的新范式，为可搜索的计算和实验nanoBIO数据集提供创新的可扩展数据库。为了优化可用资源，nanoBIO节点规划策略是在网络中组织一个网络，接触校园内的关键生物工程和生命科学团体，然后与相关的IGERT计划建立伙伴关系，多所大学的中心，和工业合作，以创造一个互动的国家结构。还与加州大学默塞德分校建立了关键的合作伙伴关系，以利用现有的研究和教育合作，并利用其基于计算生物学的本科课程。一个合作的努力，设计之间的UC-Merced和分子和细胞生物学在UIUC的学校从事材料将推动NCN成为一个革命性的生物学课堂环境，将研究与教育和刺激本科生发展跨学科的思维，反映IGERT的使命。这些丰富的在线资源也将促进在K-12教育中访问和理解nanoBIO概念。为了解决对设备和系统的关注，nanoBIO节点将在计算生物学，生物设备制造和信息技术方面拥有尖端专业知识的UIUC实验室，这些实验室包括：贝克曼研究所，微纳米技术实验室，基因组生物学研究所和国家超级计算应用中心。加州大学默塞德也将发挥重要作用，创造和指导合格的代表性不足的学生对追求事业的nanoBIO学科。智力优点：一个巨大的挑战所面临的设计师和制造商的nanoBIO设备和系统是缺乏综合的计算和培训工具，解决多个长度尺度和物理复杂性所需的桥梁生物学与工程。NCN专门的nanoBIO节点的建立为解决这一问题提供了一个令人兴奋的机会，并制定了一项覆盖全国的全面计划，以支持nanoBIO研究和教育。这个NCN nanoBIO节点的愿景是形成一个活跃的社区，加速创建多学科计算工具和纳米科学和纳米工程的变革性培训材料，用于设计新型nanoBIO设备和系统，这将对我们的生活质量和环境产生积极影响。这一努力将通过促进培训对人力资源开发产生重大影响。在线工具的可用性也将使行业受益，特别是需要获得专业资源的小型企业和nanoBIO初创企业。控制医疗保健费用和改善服务的紧迫性，提供安全和充足的粮食供应的必要性，以及作为可持续能源战略一部分的高效生物燃料生产的必要性，都表明生物学是未来的关键科学，and nanotechnology纳米technology技术as the enabler使能者. nanoBIO节点的最终目标是为发现适合nanoBIO应用的设备创建资源，并培养下一代领导者，他们将把nanoBIO技术从研究转化为市场。这些都是实现医疗保健行业持续转型和振兴的关键步骤，对美国重要制造业创造新的高科技就业机会具有广泛的潜在影响。需要一批新的科学家和工程师，他们拥有多个物理和生命科学学科的专业知识，以维持这一愿景。该节点渴望成为真正创新的跨学科教育机会的催化剂，提出一个令人兴奋的教育计划，为多方面和综合的K到博士学位途径奠定基础。