BRIGE: Magnetic Resonance Imaging Assisted Dynamic Positron Emission Tomography Imaging

PI：唐静毕业院校：奥克兰大学标题：桥：磁共振成像辅助动态正电子发射断层扫描成像（PET）智力优势：正电子发射断层扫描（PET）成像定量测量人体或动物身体的生理和生物过程。尽管PET成像在临床前研究和临床诊断中具有良好的价值，但它仍然面临着两大挑战，即固有的噪声数据和有限的空间分辨率。这些问题尤其限制了动态参数估计的准确性和可靠性，因为数据被细分为更短的帧。全身PET/磁共振成像（MRI）的到来为充分利用同时获得的高分辨率解剖信息提供了新的机会。本bridge提案的研究目的是利用MRI测量的解剖信息同时研究动态PET成像中的噪声控制和分辨率恢复。本研究的重点是研究新的三维和四维时空PET图像重建方法，以改善心肌血流参数图像的估计。解剖引导的三维功能图像重建的研究将改善噪声与偏置的权衡，特别是对于没有解剖对应的功能区域。解剖引导下4D直接参数化图像重建的研究将显著提高动态PET成像估计心脏动力学参数的能力。如果成功完成，该建议将在全身PET/MRI功能成像中整合解剖信息。同时，将在无创量化心肌血流，特别是检测区域示踪剂转运减少方面取得突破，有助于冠状动脉疾病的诊断和治疗。更广泛的影响：混合PET/MRI代表了分子成像技术的前沿挑战。鉴于多模态成像的日益普及，值得注意的是，在分子成像市场上，没有任何主要参与者提供解剖学辅助的功能成像框架。该项目将成为促进功能异常解剖定位的主要动机之外的重要进一步激励，提高多模态成像的临床相关性。拟议的扩大参与活动预期将征聘和保留工程学科中代表性不足的群体。为底特律地区的高中生举办的“I See You”生物医学成像研讨会将增加历史上代表性不足的少数民族学生从事工程职业的人数。新的生物医学工程课程和生物医学成像课程将满足密歇根东南部地区学生日益增长的需求，并吸引更多的女学生学习工程。通过该项目，PI还将为按照成功吸引有才华的女性和少数民族学生的程序招聘的本科生和研究生提供研究机会。

PI: Jing TangInstitution: Oakland UniversityTitle: BRIGE: Magnetic Resonance Imaging Assisted Dynamic Positron Emission Tomography ImagingABSTRACTIntellectual Merit: Positron emission tomography (PET) imaging measures physiological and biological processes of human or animal bodies quantitatively. Despite its well-demonstrated value in preclinical studies and clinical diagnostics, PET imaging still faces two major challenges, the inherently noisy data and limited spatial resolution. These problems especially limit the accuracy and reliability of the dynamic parameter estimation due to subdivision of data into shorter frames. The arrival of integrated whole-body PET/magnetic resonance imaging (MRI) provides new opportunities to fully take advantage of the simultaneously acquired high resolution anatomical information. The research objective of this BRIGE proposal is to investigate noise control and resolution recovery simultaneously in dynamic PET imaging using MRI measured anatomical information. The proposed research focuses on investigating novel 3D and 4D spatial-temporal PET image reconstruction methods to improve estimating myocardial blood flow parametric images. The research on anatomy guided 3D functional image reconstruction will improve the noise versus bias tradeoff especially for functional regions with no anatomical correspondence. The study on anatomy guided 4D direct parametric image reconstruction will significantly improve the capability of dynamic PET imaging to estimate cardiac kinetic parameters. When successfully completed, the proposal leads the way on integrating anatomical information in functional image formation of whole-body PET/MRI. Meanwhile, it will achieve a breakthrough on non-invasively quantifying myocardial blood flow, especially on detecting reduced regional tracer transport, contributing to the diagnosis and treatment of coronary artery disease. Broader Impacts: Hybrid PET/MRI represents the frontier challenge for molecular imaging technology. Given the increasing popularity of multimodality imaging, it is worth noting that no anatomy-assisted functional image formation framework is provided by any major player in the molecular imaging market. The project will be an important further incentive beyond the primary motivation to facilitate anatomical localization of functional abnormalities, improving the clinical relevance of multimodality imaging. The proposed broadening participation activities are expected to recruit and retain underrepresented groups in the engineering discipline. The 'I See You' workshop on Biomedical Imaging for high school students from the Detroit area will increase the number of historically under-represented minority students to pursue careers in engineering. The new Biomedical Engineering curriculum and Biomedical Imaging course will meet the growing demand of students from the southeastern Michigan area and attract more female students to engineering. Through this project, the PI will also provide research opportunities for undergraduate and graduate students recruited following procedures that have successfully attracted talented female and minority students.