Sensitivity Enhancement in Nuclear Magnetic Resonance (NMR) by Para-hydrogen Induced Hyperpolarization (SenseNMR)

核磁共振（NMR）是研究生物和非生物物质的结构、组成和动力学的最有力的技术之一。尽管其广泛的应用，潜在的低灵敏度仍然是该技术的致命弱点。传统上，需要使用昂贵的超导磁体和超长的扫描时间来缓解灵敏度挑战。然而，随着液氦可用性的不确定性不断增加，很明显，NMR必须朝着围绕永磁体的可持续选择方向发展。在过去的十年中，基于这种系统的核磁共振（称为台式核磁共振）取得了重大进展，清楚地反映了核磁共振的未来。台式磁体的磁场强度（~1特斯拉）仍然比传统超导磁体低一个数量级。不幸的是，这意味着它们被归类为更差的灵敏度和意味着更长的扫描时间，可以运行到一个单一的sample.In这个项目中，我们将解决两个长期存在的问题灵敏度和高成本与NMR光谱。这将涉及到一种叫做超极化的技术的应用。本研究项目将采用新型SABRE和最近开发的SABRE-Relay方法来实现最重要的核的自旋超极化，包括1H，13 C，15 N，19 F和31 P，这些核在一系列重要的目标分子中具有特征-化学标记物，试剂，代谢物，药物等。随后，这些超极化目标将用于一系列NMR应用，从快速化学鉴定，追踪化学品去向、样品纯度分析和动力学研究。新的分析和NMR方法将被开发，以实现这些目标，结合novelinstrumentation和自动化协议。

Nuclear magnetic resonance (NMR) is one of the most powerful techniquesfor investigating the structure, composition, and dynamics of living andnon-living matter. Despite its widespread applications underlying lowsensitivity remains the achilles heel of the technique. Traditionally,highly expensive superconducting magnets in conjunction with exceedinglylong scan times are required to alleviate the sensitivity challenge.However, with ever increasing uncertainty of liquid Helium availability,it has become clear that NMR must move towards sustainable options builtaround permanent magnets. Over the last decade, NMR based on suchsystems (known as benchtop NMR) has made significant progress andclearly reflects the future of NMR. Tthe magnetic field strengths of thebenchtop magnets (~1 Tesla) are still though an order of magnitude lowerthan those of conventional superconducting magnets. Unfortunately thismeans they are categorized by even poorer sensitivity and meant for evenlonger scan times which can run into days for a single sample.In this project we will address both the long standing issues ofsensitivity and high cost associated with NMR spectroscopy. This willinvolve the application of a technique called hyperpolarization. Thisstudentship will employ the novel SABRE, and recently developedSABRE-Relay methods to achieve the spin hyperpolarization of the mostimportant nuclei including 1H, 13C, 15N, 19F and 31P which feature in anarray of important target molecules - chemical markers, agents,metabolites, drugs etc. Subsequently, these hyperpolarized targets willbe employed for a range of NMR applications from rapid chemicalidentification, tracking chemical fate, sample purity analysis andkinetic studies. Novel analytical and NMR methodologies will bedeveloped to achieve these goals in conjunction with novelinstrumentation and automation protocols.