MRI: Acquisition of Instrumentation (LC-MS/MS) for the Trace Analysis of Anthropogenic Organic Compounds and Their Metabolites in Various Complex Matrices

抽象的# 1228662 p。当前位置这台拟议的仪器将通过增加容量和能力来支持爱荷华大学对环境和生物体中微量有机化合物及其代谢物的研究。该仪器将允许在我们正在进行的项目中进行深入研究，包括植物（Zhai和Schnoor）中激素的运输和命运，杨树（Zhai和Schnoor），大鼠（Robertson）和人类血液（Hornbuckle）中多氯联苯的羟基化代谢物；极端洪水事件造成的有机污染物（Hornbuckle, Just, Schnoor）；杨树（Zhai and Schnoor）、大鼠（Robertson and Duffel）多氯联苯硫酸盐代谢物；手性多氯联苯及其代谢物的对映选择性代谢（Zhai, Schnoor, and Lehlmer）；环境中与多氯联苯相关的化合物（霍恩巴克尔，莱姆勒，索恩）和其他人。以上提到的所有有机化合物对我们的健康和环境都有潜在的巨大危害。本团队的所有研究人员将使用该LC-MS/MS来解决公众对环境和人类健康的许多关注。这些研究结果将极大地促进我们对环境中有机污染物的行为、命运和毒理机制的认识和理解，并提醒人们采取适当的防护措施。

Abstract#1228662P.I.: Guangshu ZhaiThis proposed instrument will support the body of research at The University of Iowa on trace organic compounds and their metabolites in the environment and living organisms by increasing capacity and capabilities. This instrument will allow in-depth studies within our ongoing projects, including the transport and fate of hormones in plants (Zhai and Schnoor), hydroxylated metabolites of PCBs in poplars (Zhai and Schnoor), rats (Robertson) and human blood (Hornbuckle); organic pollutants by extreme flood events (Hornbuckle, Just, Schnoor); PCBs sulfate metabolites of PCBs in poplars (Zhai and Schnoor), rats (Robertson and Duffel); the enantioselective metabolism of chiral PCBs and their metabolites (Zhai, Schnoor, and Lehlmer); PCB-related compounds in the environment (Hornbuckle, Lehmler, Thorne) and others. All the organic compounds mentioned above have the potential of great harm to our health and environment. All the researchers in this team will use this LC-MS/MS to address many public concerns on the health of environment and human beings. All the findings of these researches will greatly advance our knowledge and understanding of the behavior, fate and toxicological mechanisms of organic pollutants in the environment and alert people to take suitable protective measures.