MRI: Acquisition of Instrumentation (LC-MS/MS) for the Trace Analysis of Anthropogenic Organic Compounds and Their Metabolites in Various Complex Matrices

摘要编号1228662 P.I.：Guangshu Zai这一拟议中的仪器将通过增加容量和能力来支持爱荷华州大学对环境和生物体中痕量有机化合物及其代谢物的研究。该仪器将允许在我们正在进行的项目中进行深入研究，包括植物中激素的运输和命运（Zhai和Schnoor），杨树中多氯联苯的羟基化代谢物（Zhai和Schnoor），大鼠（罗伯逊）和人血（Hornbuckle）;极端洪水事件造成的有机污染物（Hornbuckle，Just，Schnoor）;杨树中多氯联苯的硫酸盐代谢物（Zhai和Schnoor），大鼠（Robertson和Duffel）;手性多氯联苯及其代谢物的对映选择性代谢（Zhai、Schnoor和Lehlmer）;环境中与多氯联苯有关的化合物（Hornbuckle、Lehmler、Thorne）及其他。上述所有的有机化合物都有可能对我们的健康和环境造成巨大的危害。该团队的所有研究人员将使用这种LC-MS/MS来解决许多公众对环境和人类健康的关注。这些研究成果将极大地提高我们对有机污染物在环境中的行为、归趋和毒理机制的认识和理解，并提醒人们采取适当的保护措施。

Abstract#1228662P.I.: Guangshu ZhaiThis proposed instrument will support the body of research at The University of Iowa on trace organic compounds and their metabolites in the environment and living organisms by increasing capacity and capabilities. This instrument will allow in-depth studies within our ongoing projects, including the transport and fate of hormones in plants (Zhai and Schnoor), hydroxylated metabolites of PCBs in poplars (Zhai and Schnoor), rats (Robertson) and human blood (Hornbuckle); organic pollutants by extreme flood events (Hornbuckle, Just, Schnoor); PCBs sulfate metabolites of PCBs in poplars (Zhai and Schnoor), rats (Robertson and Duffel); the enantioselective metabolism of chiral PCBs and their metabolites (Zhai, Schnoor, and Lehlmer); PCB-related compounds in the environment (Hornbuckle, Lehmler, Thorne) and others. All the organic compounds mentioned above have the potential of great harm to our health and environment. All the researchers in this team will use this LC-MS/MS to address many public concerns on the health of environment and human beings. All the findings of these researches will greatly advance our knowledge and understanding of the behavior, fate and toxicological mechanisms of organic pollutants in the environment and alert people to take suitable protective measures.