MRI: Acquisition of Instrumentation (LC-MS/MS) for the Trace Analysis of Anthropogenic Organic Compounds and Their Metabolites in Various Complex Matrices

摘要#1228662P.I.：广书斋：这项拟议的仪器将通过提高能力和能力，支持爱荷华大学关于环境和生物中痕量有机化合物及其代谢物的研究机构。该仪器将在我们正在进行的项目中进行深入研究，包括激素在植物(翟和雪诺尔)中的迁移和去向，多氯联苯在杨树(翟和雪诺尔)、老鼠(罗伯逊)和人类血液(角巴克)中的羟化代谢物；极端洪灾事件造成的有机污染物(角巴克、贾斯特、施诺尔)；多氯联苯在杨树(翟和雪诺尔)、老鼠(罗伯逊和达菲尔)中的硫酸盐代谢产物；手性多氯联苯及其代谢物(翟志强、施诺尔和莱默尔)的对映选择性代谢；环境中与多氯联苯相关的化合物(霍恩巴克尔、莱姆勒、索恩)和其他。以上提到的所有有机化合物都可能对我们的健康和环境造成极大的危害。这个团队中的所有研究人员都将使用这种LC-MS/MS来解决公众对环境和人类健康的许多关注。所有这些研究成果都将极大地促进我们对有机污染物在环境中的行为、归宿和毒理机制的认识和理解，并提醒人们采取适当的保护措施。

Abstract#1228662P.I.: Guangshu ZhaiThis proposed instrument will support the body of research at The University of Iowa on trace organic compounds and their metabolites in the environment and living organisms by increasing capacity and capabilities. This instrument will allow in-depth studies within our ongoing projects, including the transport and fate of hormones in plants (Zhai and Schnoor), hydroxylated metabolites of PCBs in poplars (Zhai and Schnoor), rats (Robertson) and human blood (Hornbuckle); organic pollutants by extreme flood events (Hornbuckle, Just, Schnoor); PCBs sulfate metabolites of PCBs in poplars (Zhai and Schnoor), rats (Robertson and Duffel); the enantioselective metabolism of chiral PCBs and their metabolites (Zhai, Schnoor, and Lehlmer); PCB-related compounds in the environment (Hornbuckle, Lehmler, Thorne) and others. All the organic compounds mentioned above have the potential of great harm to our health and environment. All the researchers in this team will use this LC-MS/MS to address many public concerns on the health of environment and human beings. All the findings of these researches will greatly advance our knowledge and understanding of the behavior, fate and toxicological mechanisms of organic pollutants in the environment and alert people to take suitable protective measures.