Enantioselective nitrilases from filamentous fungi

来自丝状真菌的对映选择性腈水解酶

• 批准号: LP0989231
• 负责人: Prof Helena Nevalainen
• 金额: $ 4.47万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-05-12 至 2012-05-11
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0989231
• 关键词: Enantioselective; nitrilases; filamentous; fungi

The optical characteristics (chirality) of chemical precursors are important for many fine chemicals. Chiral intermediates are in high demand by the pharmaceutical and agrochemical industries for the preparation of bulk drug intermediates and agricultural products. Nitriles are attractive starting points but their conversion to corresponding amides and carboxylic acids generates significant wastes. Their hydrolysis can be performed under mild conditions by enzymes termed nitrilases. We will work on fungal nitrilases as they present a globally attractive, yet untapped commercial target. The outcome for Applimex will be a suite of biocatalysts specific for the production of key intermediates for drug and agrochemical syntheses.

化学前体的光学特性(手性)对许多精细化学品很重要。手性中间体在制药和农化工业中的需求量很大，用于制备原料药中间体和农产品。氰化物是有吸引力的起点，但它们转化为相应的酰胺和羧酸会产生大量废物。它们的水解酶可以在温和的条件下被称为丁腈酶的酶进行。我们将致力于真菌腈酶的研究，因为它们呈现了一个具有全球吸引力但尚未开发的商业目标。Applimex的成果将是一套专门用于生产药物和农用化学品合成关键中间体的生物催化剂。