Role of the proteasome in eradication of misfolded proteins in fungal cell factories

蛋白酶体在消除真菌细胞工厂中错误折叠蛋白质中的作用

• 批准号: DP0557601
• 负责人: Prof Helena Nevalainen
• 金额: $ 14.92万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-02-14 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0557601
• 关键词: Role; proteasome; eradication; misfolded; proteins

Filamentous fungi contribute to the well being of modern society as surrogate hosts for the synthesis of vaccines, hormones and enzymes for their application to health, agriculture, industry and the environment. However, attempts to express foreign proteins to the full potential of a given system have been disappointing. It is vital to understand unexplored molecular and physiological factors such as protein quality control in the cell to take advantage of the global opportunities that recombinant gene expression indisputably offers in the form of unrestricted supply of proteins of social and economic value. The project will create novel IP and licensing opportunities for Australia.

丝状真菌作为合成疫苗、激素和酶的替代宿主，为现代社会的福祉做出贡献，这些疫苗、激素和酶应用于健康、农业、工业和环境。 然而，试图表达外源蛋白质以充分发挥给定系统的潜力的尝试令人失望。 了解未探索的分子和生理因素，如细胞中的蛋白质质量控制，以利用重组基因表达无可争议地以无限制地供应具有社会和经济价值的蛋白质的形式提供的全球机会是至关重要的。该项目将为澳大利亚创造新的知识产权和许可机会。