Simultaneous Isomerization and Reactive Extraction of Biomass Sugars for Efficient Furan Production via High Yield Ketose Intermediate

生物质糖的同时异构化和反应萃取，通过高产率酮糖中间体高效生产呋喃

• 批准号: 1236708
• 负责人: Sasidhar Varanasi
• 金额: $ 30.95万
• 依托单位: University of Toledo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1236708&HistoricalAwards=false
• 关键词: Simultaneous; Isomerization; Reactive; Extraction; Biomass

PI: Varanasi, SasidharProposal Number: 1236708Institution: University of ToledoTitle: Simultaneous Isomerization and Reactive Extraction of Biomass Sugars for Efficient Furan Production via High Yield Ketose IntermediateThe cost of biofuels can be lowered by reducing the process steps needed for production. FConversion of biomass sugars with high yields to their ketose forms can immensely facilitate one-pot synthesis of fuels/chemicals. Aldose to ketose isomerization, however, has a very unfavorable equilibrium, and high yield conversion to ketoses in a manner that allows for further conversion economically has yet to be demonstrated. The goal of this project is to develop a novel simultaneous isomerization and reactive-extraction ? followed by back-extraction ? strategy that produces high yield, high concentration ketose sugars (in pure form) from biomass hydrolysate without significant energy inputs. Another feature of the technology with significant economic implications is the ability to produce separate, high-purity xylulose and fructose sugars from hydrolysate containing glucose and xylose, affording flexibility with downstream processing options. The proposed technology will allow for the direct back-extraction of ketoses into acid-containing, benign reaction media (such as room temperature ionic liquids); such media are ideal for high yield conversion of ketoses to furans under facile conditions. Hydrogenation products of these furans, such as dimethylfuran and dimethyltetrahydrofuran, are suggested as ?drop-in? liquid transportation fuels.Broader impacts of the proposed project - The potential impact of the proposed technology is immense due to its green and sustainable features. This technology (i) allows for recovery of the sugars in a form (ketose) that is readily amenable to conversion to value-added products with fewer processing steps, leading to reduced processing costs; (ii) eliminates the need for hydrolysate conditioning and the accompanying solid-waste disposal issues; (iii) eliminates energy-intensive evaporation-based sugar-concentration methods; (iv) is based the recycle and reuse of the isomerization catalyst, the sugar complexing agents, and the organic extraction media; (v) requires facile temperature and pH conditions that prevent sugar degradation and minimize cost associated with pH and temperature adjustment; and (vi) allows for in situ room temperature production of furans in high yields with no disposable waste streams.An essential part of this project is the training and education of graduate and undergraduate students. The wide scope of this project, from renewable biomass feedstock to the end product of liquid transportation fuels, will allow student researchers to acquire broad-based training in green engineering methods, analytical techniques, biomass pretreatment, enzyme catalysis, and reactions and separations. Additional outreach activities will allow for a wide dissemination of biofuels knowledge and training of students at large.

主要研究者：瓦拉纳西，撒哈拉建议书编号：1236708机构：托莱多大学标题：同时异构化和反应提取生物质糖通过高产量的酮糖中间体高效生产呋喃生物燃料的成本可以通过减少生产所需的工艺步骤来降低。将生物质糖以高产率转化为它们的酮糖形式可以极大地促进燃料/化学品的一锅合成。然而，醛糖到酮糖的异构化具有非常不利的平衡，并且以允许经济地进一步转化的方式高产率转化为酮糖还有待证明。本项目的目标是开发一种新型的同时异构化和反应萃取？然后反萃取吗这是一种从生物质水解产物生产高产率、高浓度酮糖（纯形式）而无需大量能量输入的策略。该技术具有显著经济意义的另一个特征是能够从含有葡萄糖和木糖的水解产物中生产单独的高纯度木酮糖和果糖，从而为下游加工选择提供灵活性。所提出的技术将允许将酮糖直接反萃取到含酸的良性反应介质（例如室温离子液体）中;这种介质对于在简易条件下将酮糖高产率转化为呋喃是理想的。这些呋喃的氢化产物，如二甲基呋喃和二甲基四氢呋喃，建议作为？顺便拜访液体运输燃料。拟议项目的更广泛影响-拟议技术的潜在影响是巨大的，因为它具有绿色和可持续的特点。该技术（i）允许以易于转化为具有较少加工步骤的增值产品的形式（酮糖）回收糖，从而降低加工成本;（ii）消除了对水解产物调节的需要和伴随的固体废物处置问题;（iii）消除了基于蒸发的能量密集型糖浓缩方法;（iv）基于异构化催化剂、糖络合剂和有机萃取介质的再循环和再利用;（v）需要防止糖降解并使与pH和温度调节相关的成本最小化的容易的温度和pH条件;以及（vi）允许在室温下以高产率原位生产呋喃，而没有一次性的废物流。该项目的一个重要部分是对研究生和本科生的培训和教育。该项目的范围很广，从可再生生物质原料到液体运输燃料的最终产品，将使学生研究人员获得绿色工程方法，分析技术，生物质预处理，酶催化以及反应和分离方面的广泛培训。 额外的外联活动将有助于广泛传播生物燃料知识和培训广大学生。