Simultaneous Isomerization and Reactive Extraction of Biomass Sugars for Efficient Furan Production via High Yield Ketose Intermediate

项目：Varanasi， sasidhar提案号：1236708机构：托莱多大学标题：生物质糖的同步异构化和反应性提取，通过高产酮糖中间体高效生产呋喃生物燃料的成本可以通过减少生产所需的工艺步骤来降低。将高产量的生物质糖转化为酮糖形式可以极大地促进燃料/化学品的一锅合成。醛糖到酮糖异构化，然而，有一个非常不利的平衡，和高产量转化为酮糖的方式，允许进一步转化经济尚未证明。这个项目的目标是开发一种新的同时异构化和反应萃取？然后再反拔？从生物质水解物中生产高产量、高浓度（纯形式）酮糖的策略，无需大量的能量投入。该技术具有重大经济意义的另一个特点是能够从含有葡萄糖和木糖的水解液中生产分离的高纯度木糖和果糖，为下游加工选择提供灵活性。提出的技术将允许将酮糖直接反萃取到含酸的良性反应介质中（如室温离子液体）；这种介质是理想的高产量转化为呋喃酮在便利的条件下。这些呋喃的加氢产物，如二甲基呋喃和二甲基四氢呋喃，建议作为“插入物”。液体运输燃料。拟议项目的广泛影响-拟议技术的潜在影响是巨大的，因为它具有环保和可持续发展的特点。该技术(i)允许以一种形式（酮糖）回收糖，这种形式易于转化为增值产品，加工步骤较少，从而降低了加工成本；（ii）消除对水解物调理的需要和随之而来的固体废物处理问题；（iii）消除以蒸发为基础的能源密集型浓缩糖方法；（iv）基于异构化催化剂、糖络合剂和有机萃取介质的回收和再利用；(v)需要方便的温度和pH条件，以防止糖降解，并将pH和温度调节相关的成本降至最低；并且（vi）允许在室温下以高产量原位生产呋喃，没有一次性废物流。该项目的一个重要组成部分是研究生和本科生的培训和教育。该项目范围广泛，从可再生生物质原料到液体运输燃料的最终产品，将使学生研究人员在绿色工程方法、分析技术、生物质预处理、酶催化、反应和分离方面获得广泛的培训。更多的外联活动将允许广泛传播生物燃料知识和培训广大学生。

PI: Varanasi, SasidharProposal Number: 1236708Institution: University of ToledoTitle: Simultaneous Isomerization and Reactive Extraction of Biomass Sugars for Efficient Furan Production via High Yield Ketose IntermediateThe cost of biofuels can be lowered by reducing the process steps needed for production. FConversion of biomass sugars with high yields to their ketose forms can immensely facilitate one-pot synthesis of fuels/chemicals. Aldose to ketose isomerization, however, has a very unfavorable equilibrium, and high yield conversion to ketoses in a manner that allows for further conversion economically has yet to be demonstrated. The goal of this project is to develop a novel simultaneous isomerization and reactive-extraction ? followed by back-extraction ? strategy that produces high yield, high concentration ketose sugars (in pure form) from biomass hydrolysate without significant energy inputs. Another feature of the technology with significant economic implications is the ability to produce separate, high-purity xylulose and fructose sugars from hydrolysate containing glucose and xylose, affording flexibility with downstream processing options. The proposed technology will allow for the direct back-extraction of ketoses into acid-containing, benign reaction media (such as room temperature ionic liquids); such media are ideal for high yield conversion of ketoses to furans under facile conditions. Hydrogenation products of these furans, such as dimethylfuran and dimethyltetrahydrofuran, are suggested as ?drop-in? liquid transportation fuels.Broader impacts of the proposed project - The potential impact of the proposed technology is immense due to its green and sustainable features. This technology (i) allows for recovery of the sugars in a form (ketose) that is readily amenable to conversion to value-added products with fewer processing steps, leading to reduced processing costs; (ii) eliminates the need for hydrolysate conditioning and the accompanying solid-waste disposal issues; (iii) eliminates energy-intensive evaporation-based sugar-concentration methods; (iv) is based the recycle and reuse of the isomerization catalyst, the sugar complexing agents, and the organic extraction media; (v) requires facile temperature and pH conditions that prevent sugar degradation and minimize cost associated with pH and temperature adjustment; and (vi) allows for in situ room temperature production of furans in high yields with no disposable waste streams.An essential part of this project is the training and education of graduate and undergraduate students. The wide scope of this project, from renewable biomass feedstock to the end product of liquid transportation fuels, will allow student researchers to acquire broad-based training in green engineering methods, analytical techniques, biomass pretreatment, enzyme catalysis, and reactions and separations. Additional outreach activities will allow for a wide dissemination of biofuels knowledge and training of students at large.