PFI-BIC: Partnership for Nanomembranes in Microscale Biodevices

PFI-BIC：微型生物设备中纳米膜的合作伙伴关系

• 批准号: 1237699
• 负责人: James McGrath
• 金额: $ 59.98万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1237699&HistoricalAwards=false
• 关键词: PFI; BIC; Partnership; Nanomembranes; Microscale

This Partnerships for Innovation project from the University of Rochester will focus on the application of a breakthrough membrane technology called porous nanocrystalline silicon (pnc-Si) to microscale preparative and analytical systems. In the first phase, the team will work to include the pnc-Si membranes in an existing device for portable pathogen detection. In this device the membranes will be used as a microfilter preventing aggregates from reaching detectors where they can cause false positive signals. In the second phase, the team will use the pnc-Si platform to miniaturize each step in the Integrated Nanotechnologies (INT) process to perform all reaction and detection steps on a single lab-on-a-chip device.The broader impacts of this research are many. The project is expected to decrease the time-to-market for the INT device, addressing a long-standing need of the U.S. military for remote pathogen detection from small blood samples. The miniaturized device is expected to significantly reduce costs of this device and expand its penetration into nondefense markets. More broadly, the knowledge enhancement partners (KEP) will focus on the use of pnc-Si as a platform technology for pumping and separation in lab-on-a-chip devices. This is expected to have an impact on diverse industries, from biotechnology to the food industry, where lab-on-a-chip solutions are sought to reduce the cost of complex processes. Increased demand for products from the KEP's industrial partners is expected to spur economic growth in the Rochester area. The project will also involve students in the University of Rochester's new Technical Entrepreneurship and Management program who will develop business plans, conduct market research, and perform risk assessment. The project will employ underrepresented minorities through the University of Rochester's McNair program.Partners at the inception of the project are Academic: the lead academic institution, the University of Rochester (Departments of Biomedical Engineering, Simon School of Business; Center for Entrepreneurship) and an academic partner, Rochester Institute of Technology (Departments of Electrical Engineering and Biomedical Engineering); and Small businesses: SiMPore Inc. (West Henrietta, NY), and Integrated Nanotechnologies (Henrietta, NY). SiMPore is the exclusive manufacturer of pnc-Si, an ultrathin nanoporous membrane developed at UR. The devices developed will be based on INT's proprietary process for fully automated, portable pathogen detection. Both small companies are based in the greater Rochester area. RIT faculty will provide the KEP with expertise in miniaturization, electrokinetic flows and LOC devices.

罗切斯特大学（University of Rochester）的创新项目的这种合作伙伴关系将重点介绍出一种称为多孔纳米晶硅（PNC-SI）的突破性膜技术，用于微观制备和分析系统。在第一阶段，该团队将努力将PNC-SI膜包括在现有设备中以进行便携式病原体检测。在此设备中，膜将用作微滤器，以防止聚集体到达可能引起假阳性信号的检测器。在第二阶段，团队将使用PNC-SI平台将集成纳米技术（INT）过程中的每个步骤微型化，以执行单个实验室芯片设备上的所有反应和检测步骤。这项研究的更广泛影响很多。预计该项目将降低INT设备的上市时间，以解决美国军方长期以来对从小血液样本中远程病原体检测的需求。预计该设备将显着降低该设备的成本，并将其渗透扩大到非防御市场。更广泛地说，知识增强合作伙伴（KEP）将重点介绍PNC-SI用作实验室芯片设备中泵送和分离的平台技术。预计这将对从生物技术到食品行业的各种行业产生影响，那里寻求实验室解决方案以降低复杂过程的成本。预计KEP工业合作伙伴对产品的需求增加将刺激罗切斯特地区的经济增长。该项目还将参与罗切斯特大学新的技术创业和管理计划的学生，他们将制定业务计划，进行市场研究并进行风险评估。 The project will employ underrepresented minorities through the University of Rochester's McNair program.Partners at the inception of the project are Academic: the lead academic institution, the University of Rochester (Departments of Biomedical Engineering, Simon School of Business; Center for Entrepreneurship) and an academic partner, Rochester Institute of Technology (Departments of Electrical Engineering and Biomedical Engineering);和小型企业：Simpore Inc.（纽约州西亨利埃塔）和综合纳米技术（纽约州亨利埃塔）。 Simpore是PNC-SI的独家制造商，PNC-SI是UR开发的超薄纳米膜。开发的设备将基于INT的专有过程，用于全自动，便携式病原体检测。两家小公司都位于大罗切斯特地区。 RIT教师将为KEP提供小型化，电动流和LOC设备方面的专业知识。