PFI-BIC: Partnership for Nanomembranes in Microscale Biodevices

PFI-BIC：微型生物设备中纳米膜的合作伙伴关系

• 批准号: 1237699
• 负责人: James McGrath
• 金额: $ 59.98万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1237699&HistoricalAwards=false
• 关键词: PFI; BIC; Partnership; Nanomembranes; Microscale

This Partnerships for Innovation project from the University of Rochester will focus on the application of a breakthrough membrane technology called porous nanocrystalline silicon (pnc-Si) to microscale preparative and analytical systems. In the first phase, the team will work to include the pnc-Si membranes in an existing device for portable pathogen detection. In this device the membranes will be used as a microfilter preventing aggregates from reaching detectors where they can cause false positive signals. In the second phase, the team will use the pnc-Si platform to miniaturize each step in the Integrated Nanotechnologies (INT) process to perform all reaction and detection steps on a single lab-on-a-chip device.The broader impacts of this research are many. The project is expected to decrease the time-to-market for the INT device, addressing a long-standing need of the U.S. military for remote pathogen detection from small blood samples. The miniaturized device is expected to significantly reduce costs of this device and expand its penetration into nondefense markets. More broadly, the knowledge enhancement partners (KEP) will focus on the use of pnc-Si as a platform technology for pumping and separation in lab-on-a-chip devices. This is expected to have an impact on diverse industries, from biotechnology to the food industry, where lab-on-a-chip solutions are sought to reduce the cost of complex processes. Increased demand for products from the KEP's industrial partners is expected to spur economic growth in the Rochester area. The project will also involve students in the University of Rochester's new Technical Entrepreneurship and Management program who will develop business plans, conduct market research, and perform risk assessment. The project will employ underrepresented minorities through the University of Rochester's McNair program.Partners at the inception of the project are Academic: the lead academic institution, the University of Rochester (Departments of Biomedical Engineering, Simon School of Business; Center for Entrepreneurship) and an academic partner, Rochester Institute of Technology (Departments of Electrical Engineering and Biomedical Engineering); and Small businesses: SiMPore Inc. (West Henrietta, NY), and Integrated Nanotechnologies (Henrietta, NY). SiMPore is the exclusive manufacturer of pnc-Si, an ultrathin nanoporous membrane developed at UR. The devices developed will be based on INT's proprietary process for fully automated, portable pathogen detection. Both small companies are based in the greater Rochester area. RIT faculty will provide the KEP with expertise in miniaturization, electrokinetic flows and LOC devices.

来自罗切斯特大学的创新合作项目将重点关注一种称为多孔纳米晶硅（pnc-Si）的突破性膜技术在微尺度制备和分析系统中的应用。在第一阶段，该团队将努力将pnc-Si膜纳入现有的便携式病原体检测设备中。在该设备中，膜将用作微过滤器，防止聚集体到达检测器，从而导致假阳性信号。在第二阶段，该团队将使用pnc-Si平台来简化集成纳米技术（INT）过程中的每个步骤，以便在单个芯片实验室设备上执行所有反应和检测步骤。该项目预计将缩短INT设备的上市时间，解决美国军方长期以来对少量血液样本进行远程病原体检测的需求。这种小型化的设备预计将大大降低这种设备的成本，并扩大其在非国防市场的渗透。更广泛地说，知识增强合作伙伴（KEP）将专注于使用pnc-Si作为芯片实验室设备中泵送和分离的平台技术。预计这将对从生物技术到食品工业等不同行业产生影响，这些行业寻求芯片实验室解决方案以降低复杂工艺的成本。KEP的工业合作伙伴对产品需求的增加预计将刺激罗切斯特地区的经济增长。该项目还将涉及罗切斯特大学新的技术创业和管理课程的学生，他们将制定商业计划，进行市场研究，并进行风险评估。该项目将通过罗切斯特大学的麦克奈尔项目雇用代表性不足的少数族裔。该项目的合作伙伴在一开始是学术：领先的学术机构，罗切斯特大学（西蒙商学院生物医学工程系;创业中心）和罗切斯特理工学院学术合作伙伴（电气工程和生物医学工程系）;和小企业：SiMPore Inc. (West亨里埃塔，NY）和Integrated Nanotechnologies（亨里埃塔，NY）。SiMPore是UR开发的pnc-Si纳米多孔膜的独家制造商。开发的设备将基于INT的专有流程，用于全自动便携式病原体检测。这两家小公司都位于大罗切斯特地区。RIT教师将为KEP提供小型化，电动流动和可编程器件方面的专业知识。