ShEEP Request for VA BIC MRI Cryoprobe

ShEEP 请求 VA BIC MRI 冷冻探头

• 批准号: 9906314
• 负责人: TIMOTHY J. HOFFMAN
• 金额: --
• 依托单位: HARRY S. TRUMAN MEMORIAL VA HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2020-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9906314
• 关键词: Air; Area; Cardiovascular Diseases; Cardiovascular system; Caring; Collaborations; Coupled; Data; Devices; Diagnosis; Diffusion Magnetic Resonance Imaging; Disease model; Elements; Eligibility Determination; Funding; Goals; Health; Helium; Hospitals; Image; Imaging technology; Individual; Infrastructure; Link; Liquid substance; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Medical; Medical Research; Medical center; Methodology; Missouri; Monitor; Mus; Noise; Nuclear; Positron-Emission Tomography; Post-Traumatic Stress Disorders; Pre-Clinical Model; Protocols documentation; Research; Research Personnel; Resolution; Rodent Model; Scientist; Sheep; Signal Transduction; Site; System; Technology; Training; Traumatic Brain Injury; Treatment Efficacy; United States National Institutes of Health; Universities; Vendor; Veterans; X-Ray Computed Tomography; base; cost; cryogenics; improved; in vivo; mild traumatic brain injury; neuroimaging; neuroinflammation; non-invasive imaging; oncology; optical imaging; pre-clinical; programs; single photon emission computed tomography; theranostics; therapy development; white matter

We are requesting funds to purchase a Bruker MRI Cryoprobe upgrade for our existing Bruker 7 Tesla small bore MRI based on the vendor quoted cost of $542,358. The upgrade is comprised of a 4 Element Array Cryoprobe compatible with a Bruker Biospect 7Tesla/20 magnet. The upgrade will include supporting hardware infrastructure comprised of an air cooled He compressor coupled to a Helium Compressor Controller that is linked directly to the Cryo Cooling Unit supplying liquid helium to the Cryoprobe device. The Cryoprobe will provide a 2 to 5 fold increase in system sensitivity (signal/noise ratio) permitting us to acquire data to generate Diffusion Tensor Imaging (DTI) maps for the assessment of neuroinflammation and the integrity of white matter tracts in rodent models of Traumatic Brain Injury (TBI). This technology will not only expand our neuroimaging capabilities but will be utilized as a critical component for neuroimaging assessment when coupled with PET and SPECT neuroimaging data obtained from preclinical models of TBI and PTSD in support of the newly established Open Field Blast Core at the Truman VA Hospital. Beyond greatly enhancing our neuroimaging capabilities, the addition of cryoprobe technology will also support expansion of ongoing cutting edge cardiovascular and theranostic nuclear oncology research programs directly related to veteran care.

我们正在申请资金，为现有的Bruker 7购买Bruker MRI冷冻探针升级 特斯拉小口径MRI基于供应商报价的542，358美元。升级包括 与Bruker Biospect 7 Tesla/20磁体兼容的4元件阵列冷冻探针。的 升级将包括支持硬件基础设施，包括空气冷却氦压缩机 连接到直接连接到低温冷却单元的氦压缩机控制器 向低温探测器提供液氦。冷冻探针将提供2到5倍的增加 系统灵敏度（信噪比）允许用户采集数据以生成扩散张量 用于评估神经炎症和白色物质完整性的成像（DTI）图 创伤性脑损伤（TBI）的啮齿动物模型中的神经束。这项技术不仅将扩大我们的 神经成像能力，但将用作神经成像评估的关键组成部分 当结合从TBI的临床前模型获得的PET和SPECT神经成像数据时， 和创伤后应激障碍，以支持新成立的开放领域爆炸核心在杜鲁门退伍军人医院。 除了大大增强我们的神经成像能力，冷冻探针技术的加入 还将支持正在进行的尖端心血管和治疗诊断核 与退伍军人护理直接相关的肿瘤学研究项目。