CPS: Synergy: Integrated Modeling, Analysis and Synthesis of Miniature Medical Devices

该项目的目标是创造一个有重点的网络物理设计环境，以加速微型医疗设备的总体开发，特别是可吞咽系统的开发。该项目开发了新的模型和工具，包括基于网络的综合模拟环境，捕捉为在人体内工作而设计的设备的计算和物理组件的交互动力学，以实现更广泛的设计空间探索，并最终降低迄今阻碍微型医疗设备系统工程的障碍。目前，只有少数具有深厚领域专业知识的精挑细选的个人创建了这些系统。我们的目标是向更广泛的社区开放这一领域，同时通过先进的工具支持创建更好的设计。该项目定义了组件模型和相应的特定于领域的建模语言，为所有硬件和软件构件的设计捕获、设计空间探索、分析和自动综合提供了一个通用框架。该项目还开发了一个丰富的、可扩展的组件和设计模板库，设计人员可以重复使用。在线设计环境将提供早期反馈，因此，它将降低试验替代方案的成本。潜在的好处不仅仅是增量(在时间和成本上)，还可以通过降低尝试非传统解决方案的风险来带来新的想法。消费电子产品的趋势，如小型化、低功耗操作和无线技术，使微型设备的设计成为可能，这些设备具有变革医学的潜力。通过侵入性更小和更准确的诊断和干预设备，可以带来变革性的社会公共卫生益处(例如，结直肠癌的早期诊断或预防心力衰竭)。这些医疗设备通过消除大的切口而倾向于自然开口或小端口，可以提高诊断筛查效率，减少疼痛和恢复时间。此外，如果成功，建议的科学方法可以扩展到任何其他对尺寸、能效和高置信度有严格要求的应用。该项目的教育计划以基于网络的设计环境为中心，该环境还将包含一个界面，供高中生在虚拟环境中实验医疗网络物理设备。学生将能够从组件库中构建医疗设备，使用直观的可视化编程语言对其进行编程，并在各种模拟环境中操作它们。在本项目框架下组织的夏令营将通过实验室中的实际动手实验来增强学生的学习体验。

The objective of this project is to create a focused cyber-physical design environment to accelerate the development of miniature medical devices in general and swallowable systems in particular. The project develops new models and tools including a web-based integrated simulation environment,capturing the interacting dynamics of the computational and physical components of devices designed to work inside the human body, to enable wider design space exploration, and, ultimately, to lower the barriers which have thus far impeded system engineering of miniature medical devices. Currently, a few select individuals with deep domain expertise create these systems. The goal is to open this field to a wider community and at the same time create better designs through advanced tool support. The project defines a component model and corresponding domain-specific modeling language to provide a common framework for design capture, design space exploration, analysis and automated synthesis of all hardware and software artifacts. The project also develops a rich and extensible component and design template library that designers can reuse. The online design environment will provide early feedback and hence, it will lower the cost of experimentation with alternatives. The potential benefit is not just incremental (in time and cost), but can lead to novel ideas by mitigating the risk of trying unconventional solutions.Trends in consumer electronics such as miniaturization, low power operation, and wireless technologies have enabled the design of miniature devices that hold the potential to revolutionize medicine. Transformational societal public health benefits (e.g., early diagnosis of colorectal cancer or prevention of heart failure) are possible through less invasive and more accurate diagnostic and interventional devices. By eliminating large incisions in favor of natural orifices or small ports, these medical devices can increase diagnostic screening effectiveness and reduce pain and recovery time. Furthermore, if successful, the proposed scientific approach can be extended to any other application, wherever size, power efficiency, and high confidence are stringent requirements. The educational plan of the project is centered on the web-based design environment that will also contain an interface for high school students to experiment with medical cyber-physical devices in a virtual environment. Students will be able to build medical devices from a library of components, program them using an intuitive visual programming language and operate them in various simulated environments. A Summer Camp organized in the framework of this project will enhance students learning experience with real hands-on experimentation in a lab.