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EFRI-PSBR: Cyanobacterial Biorefineries

EFRI-PSBR：蓝藻生物精炼厂

基本信息

批准号：
1240268
负责人：
Brian Pfleger
金额：
$ 200万
依托单位：
University of Wisconsin-Madison
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-15 至 2018-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1240268&HistoricalAwards=false
关键词：
EFRI PSBR Cyanobacterial Biorefineries

项目摘要

Technical Impacts-A useful long term vision of the chemical industry integrates the use of modern biotechnology and chemical catalysis to engineer systems where everyday fuels and chemicals are produced from renewable resources. The vision of this award, made to Professors Brian F. Pfleger, Christos Maravelias, Katherine D. McMahon, Thatcher W. Root and Andrew Greenberg of the University of Wisconsin-Madison is to develop and evaluate a biorefinery strategy using cyanobacteria to produce compounds that support a chemical industry based on photosynthesis. It will demonstrate methods for producing high-value commodity chemicals from CO2 and sunlight that will replace current petrochemical-based processes. Key fundamental questions that will guide the establishment of such a sustainable chemical economy based on photosynthetic cyanobacteria include: 1) What chemicals, i.e. final products or intermediates of value, should be made by living systems to optimize a chemical industry based on photosynthesis? 2) At what rate and fraction of theoretical yield can cyanobacteria produce target compounds? 3) What process parameters are critical to effectively scale up photosynthetic bioreactors from the laboratory to industrial size? Is there a limit to the feasible size of a photosynthetic biorefinery? 4) Can a photosynthetic biorefinery be integrated with waste remediation (e.g. municipal wastewater treatment) to simultaneously meet sustainability and environmental objectives? This award details a number of key features in the fundamental science and technology supporting their photosynthetic biorefinery vision, and is made through the Emerging Frontiers in Research and Innovation Program at NSF. Broader Impacts- In the long term the proposed work will contribute to restructuring the chemical industry away from fossil fuels and towards renewable carbon sources. In addition establishing photosynthetic biorefineries is a route for achieving energy security and maintaining national defense. Deployment of successful, commercial photosynthetic biorefineries could generate a sustainable source of fuels and chemicals without altering current agricultural practices. Impact on education and outreach has many individual strategies proposed by the PIs, including a)Integrating technoeconomic analysis and LCA into CBE process design and lab courses; b)Providing independent study and research experiences for undergraduates in the university labs; c) Mentoring an interdisciplinary undergraduate synthetic biology research team (iGEM); d) Providing summer research experiences for high-school students and teachers; and e) Recruiting students from underrepresented groups through successful, existing UW-Madison programs.

技术影响-化学工业的一个有用的长期愿景是将现代生物技术和化学催化剂的使用整合到工程系统中，其中日常燃料和化学品是从可再生资源中生产的。这个奖项的愿景，作出教授布赖恩F。放大图片作者：Christine Maravelias，凯瑟琳D.撒切尔W.威斯康星大学麦迪逊分校的鲁特和安德鲁·格林伯格将开发和评估一种生物炼制策略，利用蓝藻生产化合物，支持基于光合作用的化学工业。它将展示从二氧化碳和阳光中生产高价值商品化学品的方法，这些方法将取代目前的石化工艺。关键的基本问题，将指导建立这样一个可持续的化学经济的基础上光合蓝藻包括：1）什么化学品，即最终产品或中间体的价值，应该由生活系统，以优化化学工业的基础上光合作用？2)蓝细菌能以多大的速率和理论产率产生目标化合物？3)哪些工艺参数是将光合生物反应器从实验室有效扩大到工业规模的关键？光合生物精炼厂的可行规模是否有限制？4)光合生物精炼厂能否与废物治理（如城市污水处理）相结合，以同时满足可持续性和环境目标？该奖项详细介绍了支持其光合生物炼制愿景的基础科学和技术的一些关键特征，并通过NSF的新兴前沿研究和创新计划获得。更广泛的影响-从长远来看，拟议的工作将有助于调整化学工业，使其远离化石燃料，转向可再生碳源。此外，建立光合生物精炼厂是实现能源安全和维护国防的一条途径。部署成功的商业光合生物精炼厂可以在不改变当前农业实践的情况下产生可持续的燃料和化学品来源。对教育和外展的影响有许多个人的策略，由PI提出，包括a）将技术经济分析和LCA整合到CBE工艺设计和实验室课程; B）在大学实验室为本科生提供独立的学习和研究经验; c）指导跨学科的本科合成生物学研究团队（iGEM）; d）为高中学生和教师提供暑期研究经验;和e）通过成功的现有威斯康星大学麦迪逊分校项目从代表性不足的群体中招募学生。