EAGER: Study of Ultra-High Brightness of Fluorescent Silica Nanoparticles for the use in Bio Imaging Applications

这个EAGER提案涉及异常高亮度的荧光纳米粒子。作为一种全新的、完全不同的制造荧光纳米粒子的方法，这项研究被认为是高风险的。与此同时，由于这些粒子对广泛的光子应用（包括标记、跟踪、标记，特别是生物成像和传感）的重要性，它具有很高的潜在回报。高亮度的标记粒子是理想的，以获得更高的信噪比，从而提高灵敏度和/或传感速度，成像对比度，降低检测极限等。所提出的研究的优点在于研究二氧化硅纳米颗粒，它具有异常强的荧光发射；理解这种现象的本质；并研究这种方法在生物成像应用中的局限性。

1242214SokolovThis EAGER proposal deals with fluorescent nanoparticles of unusually high brightness. Being a substantially new and radically different approach to making fluorescent nanoparticles, this research is considered to be high risk. At the same time, it is a high potential payoff due to the importance of such particles for a broad range of photonic applications involving tagging, tracing, labeling, and particularly in biological imaging and sensing. High brightness of labeling particles is desirable to attain higher signal-to-noise ratio, and consequently, to increase sensitivity and/or speed of sensing, contrast of imaging, to decrease the limit of detection, etc. The merits of the proposed research are in the study of silica nanoparticles, which have unusually strong fluorescent emission; understanding the nature of this phenomenon; and investigating the limits of this approach for bio-imaging applications.