Novel family of cellulose acetate fluorescent nanomaterials for bioimaging applications

用于生物成像应用的新型醋酸纤维素荧光纳米材料系列

• 批准号: 1911253
• 负责人: Igor Sokolov
• 金额: $ 49.65万
• 依托单位: Tufts University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1911253&HistoricalAwards=false
• 关键词: Novel; family; cellulose; acetate; fluorescent

This project describes a methodology to design and manufacture ultra-bright fluorescent nanoparticles using cellulose acetate, an FDA-approved material for human use. The proposed work will fill the knowledge gaps in the stability, functionality, and efficacy of the novel nanoparticles for cancer detection using zebrafish xenograft models. This has a broad societal impact with a high translational potential to clinics.The investigator will develop a new family of cellulose acetate (CA) fluorescent nanomaterials that will be biocompatible, less expensive, and brighter than quantum dots for in vivo testing such as early cancer detection. Although CA is widely used in the food and medical industry, only large nanomaterials have been developed which are not good for in vivo applications as they are cleared rapidly from the body. The investigator will develop CA nanoparticles with diameters less than 100 nm. The particles will encapsulate multiple classes of dyes that will be ultrabright, photostable, and chemically stable at different chemical environment treatments.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目描述了一种使用醋酸纤维素（FDA批准的人类使用材料）设计和制造超亮荧光纳米颗粒的方法。拟议的工作将填补使用斑马鱼异种移植模型进行癌症检测的新型纳米颗粒的稳定性，功能性和有效性方面的知识空白。研究人员将开发一种新的醋酸纤维素（CA）荧光纳米材料家族，这种材料将具有生物相容性，价格更便宜，并且比量子点更亮，用于体内测试，如早期癌症检测。尽管CA广泛用于食品和医疗行业，但仅开发了大型纳米材料，这些材料不利于体内应用，因为它们会迅速从体内清除。研究者将开发直径小于100 nm的CA纳米颗粒。该颗粒将封装多种类型的染料，这些染料将在不同的化学环境处理中具有超亮、耐光和化学稳定性。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Failure to Guard: Mitochondrial Protein Quality Control in Cancer.

• DOI: 10.3390/ijms22158306
• 发表时间: 2021-08-02
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Friedlander JE;Shen N;Zeng A;Korm S;Feng H
• 通讯作者: Feng H

S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720.

• DOI: 10.3390/cells12070980
• 发表时间: 2023-03-23
• 期刊: Cells
• 影响因子: 6
• 作者: Laroche FJF;Li S;Shen N;Hwang SK;Nguyen G;Yu W;Wong CK;Quinton RJ;Berman JN;Liu CT;Singh A;Ganem NJ;Thiagalingam S;Feng H
• 通讯作者: Feng H

Ultrabright Fluorescent Silica Nanoparticles for Multiplexed Detection

• DOI: 10.3390/nano10050905
• 发表时间: 2020-05-01
• 期刊: NANOMATERIALS
• 影响因子: 5.3
• 作者: Peerzade, Saquib Ahmed M. A.;Makarova, Nadezda;Sokolov, Igor
• 通讯作者: Sokolov, Igor

Absorption of organic compounds by mesoporous silica discoids

• DOI: 10.1016/j.micromeso.2020.110379
• 发表时间: 2020-10
• 期刊: Microporous and Mesoporous Materials
• 影响因子: 5.2
• 作者: S. Palantavida;Berney Peng;I. Sokolov

Wide field-of-view volumetric imaging by a mesoscopic scanning oblique plane microscopy with switchable objective lenses.

通过具有可切换物镜的介观扫描斜平面显微镜进行宽视场体积成像。

• DOI: 10.21037/qims-20-806
• 发表时间: 2021
• 期刊: Quantitative imaging in medicine and surgery
• 影响因子: 2.8
• 作者: Shao,Wenjun;Kilic,Kivilcim;Yin,Wenqing;Wirak,Gregory;Qin,Xiaodan;Feng,Hui;Boas,David;Gabel,ChristopherV;Yi,Ji
• 通讯作者: Yi,Ji