Evolution of Metabolic Innovation: Aerobic Fermentation in Yeasts as an Example

代谢创新的演变：以酵母菌的有氧发酵为例

• 批准号: 1243588
• 负责人: Zhenglong Gu
• 金额: $ 52.84万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-15 至 2017-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1243588&HistoricalAwards=false
• 关键词: Evolution; Metabolic; Innovation; Aerobic; Fermentation

Intellectual Merits: One of the central issues in the evolutionary field is to understand the impact of duplicate genes on evolution. The proposed research will contribute to this understanding by demonstrating how gene duplication contributes to metabolic innovation and specifically to aerobic fermentation in yeast. The research builds on a kinetic modeling framework to investigate how gene duplication contributed to the evolution of novel metabolic functions. One aspect of the research will explore also the evolutionary connection of gene duplication and novel gene regulatory mechanisms and how these contribute to cellular metabolic innovation. Broader Impacts: This research will have important broader impacts. It will train students, including graduate, undergraduate and high school students. The PI is involved in multiple activities to include minority students with the hope to encourage and support a diverse next generation of evolutionary scientists. Aerobic fermentation in yeast has broader implication for agricultural and industrial industries. The link between nutrition and evolution itself represents an attractive case study for the edcuation of the public on the subject of evolution.

智力优点：进化领域的核心问题之一是理解重复基因对进化的影响。拟议的研究将通过展示基因复制如何有助于代谢创新，特别是酵母中的好氧发酵来促进这种理解。该研究建立在动力学建模框架上，以研究基因复制如何促进新代谢功能的进化。研究的一个方面还将探索基因复制和新基因调控机制的进化联系，以及这些机制如何有助于细胞代谢创新。更广泛的影响：这项研究将产生重要的更广泛的影响。它将培训学生，包括研究生、本科生和高中生。PI参与多种活动，包括少数民族学生，希望鼓励和支持多样化的下一代进化科学家。酵母的好氧发酵在农业和工业中有着广泛的应用。营养和进化之间的联系本身就代表了一个有吸引力的案例研究，以教育公众对进化的主题。