ERC-Small Business: Ultrasound-Guided Robotic Brachytherapy Needle-Insertion System with Intraoperative Re-Optimization

ERC-小型企业：具有术中重新优化功能的超声引导机器人近距离放射治疗针插入系统

• 批准号: 1246356
• 负责人: Everette Burdette
• 金额: $ 20万
• 依托单位: Acoustic MedSystems, Inc.
• 依托单位国家: 美国
• 项目类别: Fixed Amount Award
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1246356&HistoricalAwards=false
• 关键词: ERC; Small; Business; Ultrasound; Guided

Prostate cancer affects over 241,740 U.S. males annually, making it the most prevalent cancer type and second leading cause of cancer mortality in men. One frequently utilized method of treating prostate cancer is brachytherapy (BT), or implantation of radioactive seeds into the prostate. The success of brachytherapy chiefly depends on the ability to intra-operatively tailor the radiation dose to the patient's individual anatomy, i.e. adequately cover the prostate with sufficient radiation while simultaneously avoiding excessive radiation to surrounding organs. Many of the challenges that limit brachytherapy can be addressed by incorporating closed-loop feedback in the brachytherapy implant procedure. That is as seeds are implanted into the prostate, their actual positions are measured and fed back to the treatment planning system, which recalculates the dosimetry and re-optimizes the plan. This proposal leverages prior and ongoing research between the CISST ERC and Acoustic MedSystems to provide an integrated, commercially-viable system with following capabilities: (1) precise intra-operative localization of the implanted radioactive seeds; (2) intra-operative dosimetry and rapid re-optimization of the brachytherapy implant plan; and (3) the ability to accurately and efficiently execute the updated implant plan. The major goal of the improved process is to minimize human errors with a procedure that has a feedback mechanism for accurate and optimized dosimetry and robotic assistance in the delivery of needles in accordance with a re-optimized implant as the procedure progresses.

前列腺癌每年影响超过241，740名美国男性，使其成为最常见的癌症类型和男性癌症死亡率的第二大原因。 治疗前列腺癌的一种常用方法是近距离放射治疗（BT），或将放射性粒子植入前列腺。近距离放射治疗的成功主要取决于在手术中针对患者的个体解剖结构定制辐射剂量的能力，即，用足够的辐射充分覆盖前列腺，同时避免对周围器官的过度辐射。 限制近距离放射治疗的许多挑战可以通过在近距离放射治疗植入过程中引入闭环反馈来解决。 也就是说，当种子被植入前列腺时，它们的实际位置被测量并反馈到治疗计划系统，治疗计划系统重新计算剂量测定并重新优化计划。 该提案利用CISST ERC和Acoustic MedSystems之间的先前和正在进行的研究，提供具有以下功能的集成的商业可行系统：（1）植入放射性粒子的精确术中定位;（2）术中剂量测定和近距离放射治疗植入计划的快速重新优化;（3）准确有效执行更新植入计划的能力。 改进过程的主要目标是最大限度地减少人为错误，该过程具有用于准确和优化剂量测定的反馈机制，以及随着过程的进行根据重新优化的植入物在针输送中的机器人辅助。