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INSPIRE: Robust Molecular Programming: Advances in the Design and Verification of Reliable Self-Assembling Nanosystems

INSPIRE：鲁棒分子编程：可靠自组装纳米系统的设计和验证进展

基本信息

批准号：
1247051
负责人：
Jack Lutz
金额：
$ 92.5万
依托单位：
Iowa State University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2012
资助国家：
美国
起止时间：
2012-10-01 至 2017-09-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1247051&HistoricalAwards=false
关键词：
INSPIRE Robust Molecular Programming Advances

项目摘要

This INSPIRE award is partially funded by the following NSF units: the Software and Hardware Foundations Program in the Division of Computer and Communications Foundations of the Computer and Information Science and Engineering Directorate; the Bio Computing fund in the Division of Computer and Communications Foundations of the Computer and Information Science and Engineering Directorate; the Networks and Regulation Program in the Division of Molecular and Cellular Biosciences of the Biology Directorate; the fund for Biological and Computing Shared Principles (BCSP) in both the Computer and Communications Foundations of the Computer and Information Science and Engineering Directorate and the Biology Directorate; and the Office of Experimental Program to Stimulate Competitive Research (EPSCoR). Molecular programming, also known as DNA nanotechnology, exploits the information-processing capabilities of nucleic acids to design self-assembling, programmable structures and devices at the nanoscale. Research in the past few years has shown how DNA tile self-assembly can implement algorithms; how DNA strand displacement reactions can implement logic circuits, neural networks, and molecular robots; and how DNA origami can create two- and three-dimensional structures that can serve as targeted drug-delivery devices or "nano-breadboards" to which devices can be attached at specified locations. Simply stated, molecular programming is programming matter to do our bidding at molecular scales, and it is programming in the literal sense of computer science.This project will combine methods from molecular biology with methods from computer science, and especially software engineering, to begin the development of a discipline of robust molecular programming. This will be a systematic process for programming DNA nanosystems with a high level of confidence that they will do what they are supposed to do, despite the probabilistic vicissitudes of the chemical kinetics of their environments. The project will develop this robust approach to molecular programming in concert with real, cutting-edge wet-lab research in DNA nanotechnology. Methods developed by software engineers for designing and verifying reliable, asynchronous systems that scale and principles developed by theoretical computer scientists for integrating randomness with computation will be applied specifically to a fundamentally new approach to creating more complex yet more robust DNA origamis, to applications of this approach to reliable biosensors, and to a new method for modularizing computations at the nanoscale. This project's unconventional application of software engineering methods directly to DNA nanotechnology has potentially transformative benefits for making DNA nanotechnology and its anticipated applications to medicine, information technology, manufacturing, energy production, and other enterprises of twenty-first century society more productive, predictable, and safe. The project will also enhance interdisciplinary STEM education at Iowa State University and contribute to a developing biotech corridor in central Iowa.

该INSPIRE奖部分由以下NSF单位资助：计算机和信息科学与工程局计算机和通信基础部门的软件和硬件基础计划;计算机和信息科学与工程局计算机和通信基础部门的生物计算基金;生物学理事会分子和细胞生物科学司的网络和监管方案;生物和计算共享原则基金（BCSP）在计算机和信息科学与工程局和生物局的计算机和通信基础;刺激竞争研究实验计划办公室（EPSCoR）分子编程，也被称为DNA纳米技术，利用核酸的信息处理能力来设计纳米级的自组装，可编程结构和设备。过去几年的研究已经展示了DNA瓦片自组装如何实现算法; DNA链置换反应如何实现逻辑电路，神经网络和分子机器人;以及DNA折纸如何创建二维和三维结构，可以作为靶向药物输送设备或“纳米面包板”，设备可以连接在指定位置。简单地说，分子编程是在分子尺度上为我们的出价而编程的物质，它是计算机科学字面意义上的编程。该项目将联合收割机方法与计算机科学，特别是软件工程的方法相结合，开始发展一门强大的分子编程学科。这将是一个系统化的DNA纳米系统编程过程，尽管其环境的化学动力学可能会发生变化，但它们会有很高的信心去做它们应该做的事情。该项目将开发这种强大的分子编程方法，与DNA纳米技术中真实的前沿湿实验室研究相结合。由软件工程师开发的用于设计和验证可靠的异步系统的方法，以及由理论计算机科学家开发的用于将随机性与计算相结合的原理，将专门应用于创建更复杂但更强大的DNA origamis的全新方法，这种方法在可靠的生物传感器中的应用，以及在纳米级模块化计算的新方法。这个项目的非常规应用软件工程方法直接DNA纳米技术有潜在的变革性的好处，使DNA纳米技术和其预期的应用，医药，信息技术，制造业，能源生产，和其他企业的二十一世纪社会更有成效，可预测的，和安全。该项目还将加强爱荷华州州立大学的跨学科STEM教育，并为爱荷华州中部发展生物技术走廊做出贡献。